p21WAF1 is associated with CDK2 and CDK4 protein during HL-60 cell differentiation by TPA treatment

Title
p21WAF1 is associated with CDK2 and CDK4 protein during HL-60 cell differentiation by TPA treatment
Authors
J.-W. ChoY.-W. JeongK.-S. KimJ.-Y. OHJ.-C. ParkJ.-C. LeeW.-K. BaekS.-I. SuhM.-H. Suh
Keimyung Author(s)
백원기; 서성일; 서민호
Department
Dept. of Microbiology (미생물학)
Issue Date
2001
Publisher
School of Medicine
Citation
Cell Proliferation, Vol.34(5) : 267-274, 2001
Abstract
TPA-treated HL-60 cells are mainly arrested in G1 by p21WAF1 accumulation. We investigate the downstream changes following such accumulation. Increased p21WAF1 is associated with CDK2 and CDK4. pRb is dephosphorylated in the presence of p21–CDK2/4 complexes, and the Rb–E2F1 complex increases after TPA treatment, whereas the Rb–HDAC1 complex decreases slightly. Our results suggest that increased p21WAF1 is associated with CDK2/4, and that these complexes induce pRb dephosphorylation. In turn, hypophosphorylated pRb are mainly complexed with E2F1, but HDAC1 appears not to be a key component in this process.
URI
http://onlinelibrary.wiley.com/doi/10.1046/j.0960-7722.2001.00208.x/epdfhttp://kumel.medlib.dsmc.or.kr/handle/2015.oak/17044
ISSN
0960-7722
Appears in Collections:
1. 연구논문 > 1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
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