Catalase induced expression of inflammatory mediators via activation of NF-κB, PI3K/AKT, p70S6K, and JNKs in BV2 microglia

Title
Catalase induced expression of inflammatory mediators via activation of NF-κB, PI3K/AKT, p70S6K, and JNKs in BV2 microglia
Authors
Byeong-Churl JangJi-Hye PaikSang-Pyo KimDong-Hoon ShinDae-Kyu SongJong-Gu ParkMin-Ho SuhJong-Wook ParkSeong-Il Suh
Keimyung Author(s)
장병철; 박종구; 김상표; 신동훈; 송대규; 박종욱; 서성일; 서민호
Department
Dept. of Molecular Medicine (분자의학); Dept. of Pathology (병리학); Dept. of Preventive Medicine (예방의학); Dept. of Physiology (생리학); Dept. of Immunology (면역학); Dept. of Microbiology (미생물학); Chronic Disease Research Center (만성질환연구센터); Institute for Medical Science (의과학연구소)
Keywords
Catalase; Microglia; COX-2; iNOS; JNK; NF-κB; PI3K/AKT/p70S6K
Issue Date
2005
Publisher
School of Medicine
Citation
Cellular Signalling, Vol.17(5) : 625-633, 2005
Abstract
Catalase induces COX-2 or iNOS expression in some type of cells, but the mechanism remains unclear. Here we investigated the effect of catalase on COX-2 and iNOS expression in BV2 microglia and the inductive mechanism associated. Exposure of catalase to BV2 microglia induced expression of COX-2 and iNOS that was related with transcriptional up-regulation. Importantly, catalase-induced COX-2 and iNOS expression needed activations of NF-κB, PI3K/AKT, and JNKs, which were important for the transcriptional up-regulation of COX-2 and iNOS. Notably, rapamycin inhibition of p70S6K led to down-regulation of COX-2 and iNOS protein expression, but not steady-state mRNA expression and transcription, induced by catalase, suggesting that p70S6K is involved in increased COX-2 and iNOS mRNA translation by catalase. Interestingly, there was PI3K-dependent activation of AKT, p70S6K, JNKs, and NF-κB in response to catalase. These data collectively suggest catalase-induced COX-2 and iNOS expression in BV2 microglia is, in part at least, mediated through activation of multiple signaling proteins.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/17045
ISSN
0898-6568
Appears in Collections:
1. 연구논문 > 1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
1. 연구논문 > 1. School of Medicine (의과대학) > Dept. of Molecular Medicine (분자의학)
1. 연구논문 > 3. Researcher Institutues (부설연구소) > Chronic Disease Research Center (만성질환연구센터)
1. 연구논문 > 1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
1. 연구논문 > 1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. 연구논문 > 1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
1. 연구논문 > 1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
1. 연구논문 > 3. Researcher Institutues (부설연구소) > Institute for Medical Science (의과학연구소)
Files in This Item:
비공개 원문입니다.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE