Microglial Phagocytosis of Dopamine Neurons at Early Phases of Apoptosis

Title
Microglial Phagocytosis of Dopamine Neurons at Early Phases of Apoptosis
Authors
Byung Pil ChoShuei SugamaDong Hoon ShinLorraine A. DeGiorgioSung Soo KimYoon Seong KimSo Young LimKey Chung ParkBruce T. VolpeSunghee ChoTong H. Joh
Keimyung Author(s)
신동훈
Department
Dept. of Preventive Medicine (예방의학)
Issue Date
2003
Publisher
School of Medicine
Citation
Cellular and Molecular Neurobiology, Vol.23(4-5) : 551-560, 2003
Abstract
Transection of the medial forebrain bundle caused apoptosis of dopamine neurons in the rat substantia nigra. Immunohistochemical localization of activated microglia and tyrosine hydroxylase in the axotomized substantia nigra showed that activation of microglia was rapid and OX-6 (MHC-II marker)-positive and ED1 (lysosomal phagocytic marker)-positive microglia were apposed to structurally intact tyrosine hydroxylase-positive dopamine neurons, indicating microglial phagocytosis of degenerating dopamine neurons. The occurrence of microglial phagocytosis at early stages of apoptosis may indicate the evolution of apoptosis into an irreversible state. Alternatively, interventions that suppress early activation of microglia might lead to novel mechanisms for neuron protection..
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/17046
ISSN
0272-4340
Appears in Collections:
1. 연구논문 > 1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
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