Temporal Evolution of Strut Light Intensity After Implantation of Bioresorbable Polymeric Intracoronary Scaffolds in the ABSORB Cohort B Trial – An Application of a New Quantitative Method Based on Optical Coherence Tomography –

Shimpei NakataniYoshinobu OnumaYuki IshibashiJeroen EggermontYao-Jun ZhangCarlos M. CamposYun Kyeong ChoShengnan LiuJouke DijkstraJohan H.C. ReiberLaura PerkinsAlexander SheehySusan VeldhofRichard RapozaGerrit-Anne van EsHector M. Garcia-GarciaRobert-Jan van GeunsPatrick W. Serruys
Keimyung Author(s)
Dept. of Internal Medicine (내과학)
Issue Date
School of Medicine
Circulation Journal, Vol.78(8) : 1873-1881, 2014
Background:Quantitative light intensity analysis of the strut core by optical coherence tomography (OCT) may enable assessment of changes in the light reflectivity of the bioresorbable polymeric scaffold from polymer to provisional matrix and connective tissues, with full disappearance and integration of the scaffold into the vessel wall. The aim of this report was to describe the methodology and to apply it to serial human OCT images post procedure and at 6, 12, 24 and 36 months in the ABSORB cohort B trial.Methods and Results:In serial frequency-domain OCT pullbacks, corresponding struts at different time points were identified by 3-dimensional foldout view. The peak and median values of light intensity were measured in the strut core by dedicated software. A total of 303 corresponding struts were serially analyzed at 3 time points. In the sequential analysis, peak light intensity increased gradually in the first 24 months after implantation and reached a plateau (relative difference with respect to baseline [%Dif]: 61.4% at 12 months, 115.0% at 24 months, 110.7% at 36 months), while the median intensity kept increasing at 36 months (%Dif: 14.3% at 12 months, 75.0% at 24 months, 93.1% at 36 months).Conclusions:Quantitative light intensity analysis by OCT was capable of detecting subtle changes in the bioresorbable strut appearance over time, and could be used to monitor the bioresorption and integration process of polylactide struts.
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