7-Hexanoyltaxol–Eluting Stent for Prevention of Neointimal Growth An Intravascular Ultrasound Analysis From the Study to Compare REstenosis rate between QueST and QuaDS-QP2 (SCORE)

Authors
Toru KataokaEberhard GrubeYasuhiro HondaYoshihiro MorinoSeung-Ho HurHeidi N. BonneauAntonio ColomboCarlo Di MarioGiulio GuagliumiKarl E. HauptmannMark R. PitneyAlexandra J. LanskySimon H. StertzerPaul G. YockPeter J. Fitzgerald
Keimyung Author(s)
허승호
Department
Dept. of Internal Medicine (내과학)
Issue Date
2002
Publisher
School of Medicine
Citation
Circulation, Vol.106(14) : 1788-1793, 2002
Abstract
Background— Inhibition of neointimal tissue growth has been demonstrated in preliminary human feasibility studies with a stent-based polymer sleeve delivering 7-hexanoyltaxol. The Study to COmpare REstenosis rate between QueST and QuaDS-QP2 (SCORE) trial is a human, randomized, multicenter trial comparing 7-hexanoyltaxol (QP2)-eluting stents (qDES) with bare metal stents (BMS) in the treatment of de novo coronary lesions. The purpose of this substudy was to evaluate the acute expansion property and long-term neointimal responses of qDES compared with BMS as assessed by intravascular ultrasound (IVUS). Methods and Results— A total of 122 (qDES 66, BMS 56) patients were enrolled into the IVUS substudy. All IVUS images (immediately after the procedure and at 6-month follow-up) were analyzed at an independent core laboratory in a blind manner. At baseline, qDES achieved stent expansion similar to BMS. At follow-up, qDES showed reduced neointimal growth by 70% at the tightest cross section and by 68% over the stented segment (P<0.0001 for both), resulting in a significantly larger lumen in qDES than in BMS. Unlike intracoronary brachytherapy, there was no evidence of negative edge effects, unhealed dissections, or late stent-vessel wall malapposition over the stented and adjacent references segments in either group. Conclusions— Detailed IVUS analysis revealed that qDES had comparable acute mechanical and superior long-term biological effects to BMS. Although the long-term benefits and limitations of this technology require further investigation, the reduction in neointimal thickenings demonstrated that local delivery of 7-hexanoyltaxol through polymer sleeves augments conventional mechanical treatment of atherosclerotic disease. Key Words: cardiovascular diseases drugs restenosis stents ultrasonics
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/17078
ISSN
0009-7322
Appears in Collections:
1. 연구논문 > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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