16S rRNA 유전자 염기서열 분석법으로 확진한 Staphylococcus lugdunensis에 의한 감염성 심내막염 1예

Title
16S rRNA 유전자 염기서열 분석법으로 확진한 Staphylococcus lugdunensis에 의한 감염성 심내막염 1예
Other Titles
Native Valve Infective Endocarditis due to Staphylococcus lugdunensis Confirmed by 16S Ribosomal RNA Sequencing
Authors
Young Eun HaSeong-Yeol RyuKwan Soo KoEun-Jeong JooSo Yeon ParkHyun Ah KimMin-Hee LimCheol-In KangDoo Ryeon ChungJae-Hoon SongPyo-Won ParkKyong Ran Peck
Keimyung Author(s)
류성열; 김현아
Department
Dept. of Internal Medicine (내과학)
Keywords
Staphylococcus lugdunensis; Infective endocarditis; Coagulasenegative staphylococci; 16S ribosomal RNA sequencing
Issue Date
2011
Publisher
School of Medicine
Citation
Infection and Chemotherapy, Vol.43(4) : 372-376, 2011
Abstract
Staphylococcus lugdunensis is a Gram-positive, coagulase-negative Staphylococcus (CNS) species that is found as a skin commensal and has been implicated in fulminant invasive diseases such as infective endocarditis. S. lugudunensis infections resemble Staphylococcus aureus infections in terms of virulence, tissue destruction and clinical course. Although correct identification and determination of the susceptibility profile are important, some commercial systems may misidentify S. lugdunensis . We report a case of native valve infective endocarditis caused by S. lugdunensis , which was misidentified by the Vitek 2 system but identified correctly by 16S ribosomal RNA (rRNA) gene sequencing in a 72-year-old male patient. The patient had multiple vegetations on his mitral valve, and the largest one was found on the posterior mitral valve leaflet. It was 2.5 cm in size and hypermobile. Diffuse valvular abscess was also observed. He had persistent bacteremia for appoximately 8 days, which was resolved after immediate surgery and antibiotic therapy. When a patient with severe sepsis syndrome grows S. aureus or CNS other than S. lugdunensis on a commercial automatic culture system, the possibility of S. lugdunensis should be considered and further confirmatory testing such as 16S rRNA sequencing may be very useful.
URI
http://synapse.koreamed.org/Synapse/Data/PDFData/0086IC/ic-43-372.pdfhttp://kumel.medlib.dsmc.or.kr/handle/2015.oak/17532
ISSN
2093-2340
Appears in Collections:
1. 연구논문 > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
Files in This Item:
oak-aaa-02033.pdf(767.97 kB)Download
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE