Association between Serum Irisin Levels and Non-Alcoholic Fatty Liver Disease in Health Screen Examinees

Title
Association between Serum Irisin Levels and Non-Alcoholic Fatty Liver Disease in Health Screen Examinees
Authors
Eun Sung ChoiMi Kyung KimMin Kyung SongJeong Min KimEun Soo KimWoo Jin ChungKyung Sik ParkKwang Bum ChoJae Seok HwangByoung Kuk Jang
Keimyung Author(s)
김미경; 김은수; 정우진; 박경식; 조광범; 황재석; 장병국
Department
Dept. of Internal Medicine (내과학); Institute for Cancer Genetics (암연구소)
Issue Date
2014
Publisher
School of Medicine
Citation
PLOS ONE, Vol.9(10) : e110680, 2014
Abstract
Irisin is a recently found myokine that aids obesity control and improves glucose homeostasis by acting on white adipose tissue cells and increases total energy consumption. The aim of this study was to evaluate serum irisin levels in patients with non-alcoholic fatty liver disease (NAFLD) and to compare these levels with those of normal controls. Among 595 health screen examinees who had visited our institute between January 2013 to March 2013, 355 patients (84 NAFLD patients and 271 normal controls) were enrolled depending on whether they gave written informed consents and their history of alcohol intake, blood tests, and abdominal ultrasonographic findings. Age; sex; laboratory test parameters; homeostasis model assessment-insulin resistance; and levels of leptin, adiponectin, and irisin were assessed. Serum irisin levels (ng/ml) were significantly higher in the NAFLD group than in normal controls (63.4±32.6 vs. 43.0±29.7, p<0.001) and higher in the mild fatty liver group than in the moderate-to-severe fatty liver group (68.3±38.2 vs. 56.6±21.2, p<0.001). Additionally, serum irisin levels were not different between the non-obese and obese groups (48.4±34.2 vs. 45.8±22.9, p = 0.492); however, the levels were significantly lowest in normal controls and highest in the mild fatty liver group in the non-obese (44.9±31.7 vs. 73.1±48.5 vs 59.7±18.0, p<0.001) and obese groups (35.0±17.0 vs. 62.9±21.2 vs. 54.6±23.3, p<0.001). Serum irisin levels were significantly higher in NAFLD patients, which is not consistent with the results of previously published studies. Therefore, more studies are needed to confirm the role of irisin in NAFLD.
URI
http://journals.plos.org/plosone/article/asset?id=10.1371%2Fjournal.pone.0110680.PDFhttp://kumel.medlib.dsmc.or.kr/handle/2015.oak/21493
ISSN
1932-6203
Appears in Collections:
1. 연구논문 > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. 연구논문 > 3. Researcher Institutues (부설연구소) > Institute for Cancer Research (암연구소)
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