자궁경부암에서 인유두종바이러스 감염과 p53, p21WAF1 및 p16INK4a 유전자 돌연변이 검색

Other Titles
Mutational Analysis of p53, p21WAF1 and p16INK4a in Human Cervical Carcinomas
Authors
서성일최은주백원기서민호조치흠이태성차순도
Keimyung Author(s)
서성일; 백원기; 서민호; 조치흠; 이태성; 차순도
Department
Dept. of Microbiology (미생물학); Dept. of Obstetrics & Gynecology (산부인과학); Institute for Medical Science (의과학연구소); Institute for Medical Genetics (의학유전학연구소)
Keywords
Cervical carcinoma; p53; p21WAF1; p16INK4a; Mutation analysis; HPV
Issue Date
1998
Publisher
School of Medicine
Citation
대한미생물학회, Vol.33(4) : 415-423, 1998
Abstract
Human papillomavirus (HPV) infection has been implicated to be an important causative factor for the development of cervical carcinoma. P53 gene mutation is common in human malignancies, and it is suggested that p53 function is inactivated either by complex formation with HPV E6 product or by gene mutation in cervical carcinoma. Forty-six cervical carcinoma samples were evaluated for the presence of mutations in p53,p21WAF1 and p16INK4a genes with polymerase chain reaction (PCR), single stranded conformational polymorphism (SSCP) analysis and DNA sequencing. The status of HPV infection in tumor tissues was analysed by PCR. Forty-two of 46 cervical mobility-shifted band in PCR-SSCP analysis of p53, p21WAF1 and p16INK4a mutational inactivation. But it remains to be determined whether disruption of the 3’UTR of p16INK4a mRNA leads to an increased risk for cervical carcinomas.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/23319
ISSN
0253-3162
Appears in Collections:
1. 연구논문 > 1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
1. 연구논문 > 1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
1. 연구논문 > 3. Researcher Institutues (부설연구소) > Institute for Medical Genetics (의학유전학연구소)
1. 연구논문 > 3. Researcher Institutues (부설연구소) > Institute for Medical Science (의과학연구소)
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