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dc.contributor.author서성일-
dc.contributor.author최은주-
dc.contributor.author백원기-
dc.contributor.author서민호-
dc.contributor.author조치흠-
dc.contributor.author이태성-
dc.contributor.author차순도-
dc.contributor.authorSeong-Il Suh-
dc.contributor.authorEun-Joo Choi-
dc.contributor.authorWon-Ki Baek-
dc.contributor.authorMin-Ho Suh-
dc.contributor.authorChi-Heum Cho-
dc.contributor.authorTae-Sung Lee-
dc.contributor.authorSoon-Do Cha-
dc.date.accessioned2018-01-30T07:38:40Z-
dc.date.available2018-01-30T07:38:40Z-
dc.date.issued1998-
dc.identifier.citation대한미생물학회 The Korean Society For Microblology, Vol.33(4) : 415-423, 1998-
dc.identifier.issn0253-3162-
dc.identifier.otheroak-bbb-885-
dc.identifier.urihttp://kumel.medlib.dsmc.or.kr/handle/2015.oak/23319-
dc.description.abstractHuman papillomavirus (HPV) infection has been implicated to be an important causative factor for the development of cervical carcinoma. P53 gene mutation is common in human malignancies, and it is suggested that p53 function is inactivated either by complex formation with HPV E6 product or by gene mutation in cervical carcinoma. Forty-six cervical carcinoma samples were evaluated for the presence of mutations in p53,p21WAF1 and p16INK4a genes with polymerase chain reaction (PCR), single stranded conformational polymorphism (SSCP) analysis and DNA sequencing. The status of HPV infection in tumor tissues was analysed by PCR. Forty-two of 46 cervical mobility-shifted band in PCR-SSCP analysis of p53, p21WAF1 and p16INK4a mutational inactivation. But it remains to be determined whether disruption of the 3’UTR of p16INK4a mRNA leads to an increased risk for cervical carcinomas.-
dc.description.statementofresponsibilityrestriction-
dc.publisherSchool of Medicine-
dc.rightsBY_NC_ND-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.0/kr-
dc.subjectCervical carcinoma-
dc.subjectp53-
dc.subjectp21WAF1-
dc.subjectp16INK4a-
dc.subjectMutation analysis-
dc.subjectHPV-
dc.title자궁경부암에서 인유두종바이러스 감염과 p53, p21WAF1 및 p16INK4a 유전자 돌연변이 검색-
dc.title.alternativeMutational Analysis of p53, p21WAF1 and p16INK4a in Human Cervical Carcinomas-
dc.typeArticle-
dc.contributor.localauthor서성일-
dc.contributor.localauthor백원기-
dc.contributor.localauthor서민호-
dc.contributor.localauthor조치흠-
dc.contributor.localauthor이태성-
dc.contributor.localauthor차순도-
dc.contributor.alternativelocalauthorSuh, Seong Il-
dc.contributor.alternativelocalauthorBaek, Won Ki-
dc.contributor.alternativelocalauthorSuh, Min Ho-
dc.contributor.alternativelocalauthorCho, Chi Heum-
dc.contributor.alternativelocalauthorLee, Tae Sung-
dc.contributor.alternativelocalauthorCha, Soon Do-
dc.contributor.departmentDept. of Microbiology (미생물학)-
dc.contributor.departmentDept. of Obstetrics & Gynecology (산부인과학)-
dc.contributor.departmentInstitute for Medical Science (의과학연구소)-
dc.contributor.departmentInstitute for Medical Genetics (의학유전학연구소)-
dc.citation.volume33-
dc.citation.number4-
dc.citation.startpage415-
dc.citation.title대한미생물학회 The Korean Society For Microblology-
dc.citation.endpage423-


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