HL-60 세포주의 분화유도에 따른 IAP 유전자군의 발현

Title
HL-60 세포주의 분화유도에 따른 IAP 유전자군의 발현
Other Titles
Expression of IAP Genes During TPA-Induced Differentiation of HL-60 Cells
Authors
백원기권택규박종욱서민호Won-Ki BaekTaeg Kyu KwonJong-Wook ParkMin-Ho Suh
Keimyung Author(s)
백원기; 서민호; 권택규; 박종욱
Department
Dept. of Microbiology (미생물학); Dept. of Immunology (면역학)
Keywords
Differentiation; IAP; HL-60; Apoptosis
Issue Date
2003
Publisher
School of Medicine
Citation
Journal of Bacteriology and Virology, Vol.33(1) : 113-118, 2003
Abstract
HL-60 cells (human promyelocytic leukemia cells) differentiate into the monocyte/macrophage like cells that die spontaneously by apoptosis when treated with 12-O-tetradecanoylphorbol-13-acetate (TPA). It is known that inhibitors of apoptosis proteins (IAP) bind to and inhibit caspase 3,7,9 activity and the induction of apoptosis. In this study, we examined the expression of IAP genes during TPA induced differentiation of HL-60 cells. During the differentiation, HIAP-1, HIAP-2, and XIAP expressions were decreased in protein levels. The pan-caspase inhibitor z-VAD-fmk blocked the decrease of HIAP-1 and HIAP-2, which indicates HIAP-1 and HIAP-2 could be caspase substrates. These findings suggest that the decrease of IAP proteins is related to the induction of apoptosis that is associated with TPA- induced HL-60 cell differentiation.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/23328
ISSN
1598-2467
Appears in Collections:
1. 연구논문 > 1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
1. 연구논문 > 1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
Files in This Item:
비공개 원문입니다.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE