Vibrio vulnificus에 대한 항균제의 작용과 그 병합효과

Title
Vibrio vulnificus에 대한 항균제의 작용과 그 병합효과
Other Titles
Antimicrobial Activity and Combination Effect of Drugs to Vibrio vulnificus
Authors
하대유온기곤황희성박종욱Tai You HAKi Kon OwnHee-Sung WhangJong-Wook Park
Keimyung Author(s)
박종욱
Department
Dept. of Immunology (면역학)
Keywords
Vibrio vulnificus; Antibiotics; Combination drug effect
Issue Date
1991
Publisher
School of Medicine
Citation
대한미생물학회 The Korean Society For Microblology, Vol.26(6) : 519-530, 1991
Abstract
Thirty eight strains of Vibrio vulnificus isolated from various specimen were tested for antimicrobial susceptibility to 12 drugs by microdilution broth method. Against most of the strains tested, tetracycline (Tc), moxalactam (Mx), cefamandole (Cf), chloramphenicol (Cm), gentamicin (Gm0, cephalothin (Ct), and tobramycin (To) showed good antimicrobial effect, and streptomycin, ampicillin showed intermediate antibacterial effect or resistance. In order to search for combined antimicrobial activity between Tc and other drugs to Vibrio unlnificus, about 20 strains randomly activity with Tc, but Ct-Tc or To-Tc showed no antagonistic activity on all of strains tested, and they showed synergistic activity against 1 and 2 strains, respectiviely. These results suggest that single administration of Tc, Mx, Cf, Cm and Gm, or Tc-Ct and Tc-To combined medication can be useful for the treatment of Vibrio vulnificus infections.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/23332
ISSN
0253-3162
Appears in Collections:
1. 연구논문 > 1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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