인체대장암의 암유전자와 항암유전자의 분자유전적 특성 및 발현

Other Titles
Molecular Characteristics of Oncogenes and p53 Antioncogene in Korean Colorectal Cancers
Authors
백원기서성일서민호
Keimyung Author(s)
백원기; 서성일; 서민호
Department
Dept. of Microbiology (미생물학); Institute for Medical Science (의과학연구소)
Keywords
Colorectal cancer; Ras; Myc; Fos; p53
Issue Date
1995
Publisher
School of Medicine
Citation
대한미생물학회, Vol.30(6) : 727-735, 1995
Abstract
To define the role of cellular oncogenes and tumor suppressor genes in human colorectal canc¬ers, genetic alterations of ras, myc, fos oncogenes and p53 antioncogene in 30 freshly isolated primary colorectal cancer tissues were studied by using various molecular methods. In Southern blot hybridization, modest amplifications of c-myc gene(40%) were found in cancer tissues but no amplification and rearrangement of c-Ha-ras, c-fos and p53 genes were observed. In RNA slot blot analysis, 47% of cases showed significantly elevated expression of c-myc gene and 12% of cases showed modest elevated level of c-Ha-ras gene transcripts. These results suggested that amplification/overexpression of c-myc gene and elevated expression of c-Ha-ras gene were involved in tumor development of Korean colorectal cancers.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/23338
ISSN
0253-3162
Appears in Collections:
1. 연구논문 > 1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
1. 연구논문 > 3. Researcher Institutues (부설연구소) > Institute for Medical Science (의과학연구소)
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