방광암 환자에서 BCG를 이용한 면역요법연구

Title
방광암 환자에서 BCG를 이용한 면역요법연구
Other Titles
Therapy of BCG (bacillus Calmette-Guerin) for Superficial Transitional Cell Carcinoma of the Bladder
Authors
박철희이성준
Issue Date
1988
Publisher
Keimyung University School of Medicine
Citation
Keimyung Medical Journal, Vol.7(1) : 31~37, 1988
Abstract
Intravesical bacillus Calmette-Guerin (BCG) has been shown to be effective therapy and prophylaxis against recurrent tumor in patients with superficial bladder cancer (stages 0 and A); including carcinoma in situ. Tice-Chicago strain BCG was used to treat superficial transitional cell carcinoma of the bladder in 24 patients between July; 1985 and June; 1987. A variety of different BCG treatment regimens have been used that vary in intensity. In general; treatment results have heen more favorable with intensive regimens. However; the toxicity also has been substantially greater with intensive regimens. The optimal regimen has yet to be determined. Our treatment regimen of 120mg. Tice-Chicago strain BCG weekly for 6 weeks and then monthly for 3 months was well tolerated. 23 patients had a complete response and one had a tumor recurrence at 18 months follow-up; resulting in 96% of response rate. Side effects during or shortly after treatment were minor and self-limiting in the majority of patients (fever; bladder irritability and hematuria). This experience supports the efficacy of BCG as a cost effective; well-tolerated treatment modality for patients with superficial transitional cell carcinoma of the bladder.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/2531
Appears in Collections:
학술지 > 1988
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