IgA Nephropathy의 증후군: 면역병리학적 연구

Title
IgA Nephropathy의 증후군: 면역병리학적 연구
Other Titles
Syndrome of IgA nephropathy —Immunohistopathological study—
Authors
장은숙
Issue Date
1988
Publisher
Keimyung University School of Medicine
Citation
Keimyung Medical Journal, Vol.7(2) : 335~349, 1988
Abstract
Since Berger and Hinglais published the first account of IgA nephropathy in 1968; IgA nephropathy has been recognized as a distinct form of primary glomerular disease and is recognized as the most common form of glomerulonephritis. The diagnostic features of primary IgA nephritis are mesangial deposits of IgA; mesangial expansion and proliferation with variable acute proliferative and sclerotic glomerular lesions in absence of systemic disease; but mesangial deposits are also seen in Henᄋch-Schonlein purpura and systemic lupus erythematosus and in association with certain other disease such as hepatobiliary disorder. It has now become clear that several different clinical conditions share this common immunopathology. Several possible immnuopathogenesis have been found and it felt that IgA nephropathy should be regarded as a syndrome. IgA immune complex is the most important pathogenical role in glomerulonephritis with mesangial IgA deposits. Several hypotheses have been proposed to explain the occurence of nephritogenic IgA class immune complexes. Increased production of IgA due to an impaired immunᄋregulation and physiological immune response to acute antigen exposure; and decreased clearance of IgA due to impaired macrophage function. Activation of the alternative pathway of complement cascade in IgA nephropathy can result hypoco-mplementemia in active cases and the deposition of complement is induced by IgG/IgM codeposits; the deposition of complement is required for glomerular injury which is responsible for the alterations in glomerular function. 41 cases of renal biopsy specimens were selected out of 133 renal biopsy cases and summerized with correlation to their light microscopic and immunofluorescence findings; which obtained the period of Sep. 1986-Oct. 1988 at the department of Pathology; Keimyung University; Dongsan Hospital; Taege; Korea. The results were as follows: 1) The incidence of IgA nephropathy was 30. 8% of all renal biopsy cases. 2) Sex distribution showed slight male preponderance with male: female ratio of 1. 05 : 1. 3) Age distribution were 0—9 years 2. 4%; 10-19 years 19.5%; 20—29 years 46.3%; 30—39 years 14.6%; 40—49 years 7.3%; 50—59 years 7.3%; 60—69 years 2.4%. The young age group of age 10—29 years was the most prevalent. 4) The clinical symptoms were hematuria 71.8%; proteinuria (below lg/day) 4.9%; the rest above lg/day; nephrotic syndrome 24.3%; edema without nephrotic syndrome 31.7%. 5) The distributions of light microscopic findings were minimal change 19.5%t mesangial proliferation 36. 6%; focal/segmental proliferation 7.3%; diffuse proliferation 17.1%; sclerosis 12.2% and crescents 2.4%. 6) Immunofluorescence study showed significant granular mesangial deposits of IgA and IgM 100%; IgG 75.6%; C3 80.4%; fibrinogen 63.4%.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/2570
Appears in Collections:
학술지 > 1988
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