정신지체가 동반된 간질 환자의 측두엽절제술의 예후

Other Titles
Prognosis of Temporal Lobectomy for Temporal Lobe Epilepsy Patients with Mental Retardation
Authors
장상섭이장준김지언이상도박영춘
Keimyung Author(s)
김지언; 이상도; 박영춘
Department
Dept. of Neurology (신경과학)
Keywords
Mental retardation; Mesial temporal lobe epilepsy; Surgical outcome
Issue Date
2000
Publisher
School of Medicine
Citation
대한신경과학회지, Vol.18(5) : 595-600, 2000
Abstract
Background : For decades, patients with epilepsy and mental retardation (MR) have been considered as a relative contraindication for focal resective epilepsy surgery. However, considerable debate exists concerning whether the presence of MR is a contraindication for epilepsy surgery or not. We examined the postsurgical seizure outcome of temporal lobe epilepsy (TLE) according to preoperative intelligence scores and the relationship between preoperative intelligence and postsurgical seizure outcomes of TLE. Methods : We investigated 131 patients with TLE divided into two groups according to standard IQ ranges and seizure outcomes were compared by Engel’s classification. Results : The percentage of seizure free patients after surgery was 66.4% in all patients and the percentage in patients with and without MR were 60.7% and 68%, respectively. The age at seizure onset was significantly different between the MR group and non the MR group. However, other factors which have been thought to affect the intelligence of patients with TLE were not significantly different between the two groups. The best postoperative seizure outcome was shown in the borderline group, where the frequency of hippocampal sclerosis and age at seizure onset were significantly higher compared to the other groups. Conclusions : Although preoperative MR has been regarded as a predictor for a poor prognosis of surgical outcome, our results suggest that MR alone is not a contraindication for epilepsy surgery. Therefore, epilepsy patients with MR who meet other inclusion criteria for epilepsy surgery should not be rejected for epilepsy surgery.
URI
http://www.jkna.org/upload/pdf/200005012.pdfhttp://kumel.medlib.dsmc.or.kr/handle/2015.oak/27421
ISSN
1225-7044
Appears in Collections:
1. 연구논문 > 1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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