Polyacrylamide hydrogel is a widely used filler material in
cosmetic procedures performed on the face and breasts.
Recently, however, complications including inflammation,
deformity, and pain have been reported. The present article
addresses unregulated materials/products injected as dermal
fillers. The authors report a case involving a 29-year-old woman
who developed severe facial pain after undergoing a cosmetic
procedure with injectable triamcinolone and hyaluronidase. Two
months later, the pain spread to her upper and lower limbs, and
abdomen, which eventually led to the the development and
diagnosis of complex regional pain syndrome (CRPS) in the
upper limbs. The authors hypothesize that CRPS in the upper
limbs was responsible for the facial pain through sensitization of
third-order neurons and the trigeminal nucleus caudalis
extending to the upper cervical segments.