The Impact of High-Risk HPV Genotypes Other Than HPV 16/18 on the Natural Course of Abnormal Cervical Cytology: A Korean HPV Cohort Study
- Affiliated Author(s)
- 조치흠
- Alternative Author(s)
- Cho, Chi Heum
- Journal Title
- Cancer Res Treat
- ISSN
- 1598-2998
- Issued Date
- 2016
- Keyword
- Human papillomavirus; Genotype; Cytology
- Abstract
- Purpose.
The purpose of this study is to evaluate the impact of high-risk human papillomaviruses
(HPVs) other than HPV 16/18 on the natural course of atypical squamous cells of undetermined
significance (ASC-US) or low-grade squamous intraepithelial lesion (LSIL).
Materials and Methods.
The study population was derived from the Korean HPV cohort (2010-2014). Women aged
20 to 60 who satisfied the criteria of having both HPV infection and abnormal cervical
cytology of either ASC-US or LSIL were recruited from five institutions nationwide. Enrolled
patients underwent cervical cytology and HPV DNA testing every 6 months.
Results.
A total of 1,158 patients were enrolled. The 10 most common HPV types were HPV
16 (12.3%), 58 (10.0%), 56 (8.8%), 53 (8.4%), 52 (7.7%), 39 (6.2%), 18 (6.0%), 51 (5.7%),
68 (5.1%), and 66 (4.6%). Among these patients, 636 women were positive for high-risk
HPVs other than HPV 16 or 18, and 429 women were followed for more than 6 months.
Cytology evaluations showed progression in 15.3% of women, no change in 22.6%, and
regression in 62.1% of women at 12 months. In cases of HPV 58 single infection, a more
highly significant progression rate, compared to other high-risk types, was observed at
6 months (relative risk [RR], 3.3; 95% confidence interval [CI], 2.04 to 5.30; p < 0.001) and
12 months (RR, 5.03; 95% CI, 2.56 to 9.91; p < 0.001).
Conclusion.
HPV genotypes numbered in the 50s were frequent in Korean women with ASC-US and
LSIL. HPV 58 was the second most common type, with a high progression rate of cervical
cytology.
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