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Recent Insights into Insulin-Like Growth Factor Binding Protein 2 Transcriptional Regulation

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Affiliated Author(s)
배재훈박재형임승순송대규
Alternative Author(s)
Song, Dae KyuBae, Jae HoonPark, Jae HyungIm, Seung Soon
Journal Title
Endocrinology and Metabolism
ISSN
2093-596X
Issued Date
2017
Keyword
Insulin-like growth factor binding protein 2Transcriptional regulationMetabolic diseasesLiver
Abstract
Insulin-like growth factor binding proteins (IGFBPs) are major regulators of insulin-like growth factor bioavailability and activity in metabolic signaling. Seven IGFBP family isoforms have been identified. Recent studies have shown that IGFBPs play a pivotal role in metabolic signaling and disease, including the pathogenesis of obesity, diabetes, and cancer. Although many studies have documented the various roles played by IGFBPs, transcriptional regulation of IGFBPs is not well understood. In this review, we focus on the regulatory mechanisms of IGFBP gene expression, and we summarize the findings of transcription factor activity in the IGFBP promoter region.
Department
Dept. of Physiology (생리학)
Publisher
School of Medicine
Citation
Minsang Shin et al. (2017). Recent Insights into Insulin-Like Growth Factor Binding Protein 2 Transcriptional Regulation. Endocrinology and Metabolism, 32(1), 11–17. doi: 10.3803/EnM.2017.32.1.11
Type
Article
ISSN
2093-596X
DOI
10.3803/EnM.2017.32.1.11
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32400
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
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