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Optimal First-Line Treatment for Helicobacter pylori Infection: Recent Strategies

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Affiliated Author(s)
박경식이주엽
Alternative Author(s)
Park, Kyung SikLee, Ju Yup
Journal Title
Gastroenterology Research and Practice
ISSN
1687-6121
Issued Date
2016
Abstract
A new treatment strategy is needed, as the efficacy of triple therapy containing clarithromycin—the current standard treatment for Helicobacter pylori infection—is declining. Increasing antibiotic resistance of H. pylori is the most significant factor contributing to eradication failure. Thus, selecting the most appropriate regimen depending on resistance is optimal, but identifying resistance to specific antibiotics is clinically challenging. In a region suspected to have high clarithromycin resistance, bismuth quadruple therapy and so-called nonbismuth quadruple therapies (sequential, concomitant, and sequential-concomitant hybrid) are some first-line regimen options. However, more research is needed regarding appropriate second-line treatments after first-line treatment failure. Tailored therapy, which is based on antibiotic sensitivity testing, would be optimal but has several limitations for clinical use, and an alternative technique is required. A novel potassium-competitive acid blocker-based eradication regimen could be a valuable eradication option in the near future
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
Ju Yup Lee and Kyung Sik Park. (2016). Optimal First-Line Treatment for Helicobacter pylori Infection: Recent Strategies. Gastroenterology Research and Practice, 2016, 9086581–9086581. doi: 10.1155/2016/9086581
Type
Article
ISSN
1687-6121
DOI
10.1155/2016/9086581
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32406
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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