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PMK-S005 Alleviates Age-Related Gastric Acid Secretion, Inflammation, and Oxidative Status in the Rat Stomach

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Author(s)
이주엽
Alternative Author(s)
Lee, Ju Yup
Issued Date
2016
Keyword
s-allyl-l-cysteineAgingGastric acidAnti-inflammationAntioxidants
Abstract
Background/Aims : The aim of this study was to evaluate the effect of the synthetic S-allyl-l-cysteine (SAC) PMK-S005 on gastric acid secretion, inflammation, and antioxidant enzymes in aging rats.
Methods : The rats were divided into four groups at 31 weeks of age and were continuously fed a diet containing a vehicle control, PMK-S005 (5 or 10 mg/kg), or lansoprazole (5 mg/kg). Gastric acid secretion and connective tissue thickness of the lamina propria were evaluated at 74 weeks and 2 years of age. Tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and COX-2 levels were measured by using enzyme-linked immunosorbent assays (ELISAs) or Western blot assays. Levels of antioxidant enzymes, including heme oxyganase 1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO-1), were also measured.
Results : As the rats aged, gastric acid secretion significantly decreased, and the connective tissue of the lamina propria increased. However, 74-week-old rats in the PMK-S005 group exhibited greater levels of gastric acid secretion than those of the control and lansoprazole groups. The increase of TNF-α, IL-1β, and COX-2 expression in 74-week and 2-year-old control rats were inhibited by PMK-S005. In addition, the decrease in HO-1 and NQO-1 protein expression that occurred with aging was inhibited by PMK-S005 in the 74-week-old rats.
Conclusions : These results suggest that PMK-S005 has therapeutic potential as an antiaging agent to ameliorate age-related gastric acid secretion, inflammation, and oxidative stress in the stomach.
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
Gut and Liver, Vol.10(5) : 749-756, 2016
Type
Article
ISSN
1976-2283
DOI
10.5009/gnl15584
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/32410
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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