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Comparison of Pallidal and Subthalamic Deep Brain Stimulation in Parkinson’s Disease: Therapeutic and Adverse Effects

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Affiliated Author(s)
유수연
Alternative Author(s)
You, Soo Yeoun
Journal Title
Journal of Movement Disorders
ISSN
2005-940X
Issued Date
2017
Keyword
Parkinson’s diseasedeep brain stimulationglobus pallidus internasubthalamic nucleus
Abstract
Objective:To compare the therapeutic and adverse effects of globus pallidus interna (GPi) and subthalamic nucleus (STN) deep brain stimulation (DBS) for the treatment of advanced Parkinson’s disease (PD).
MethodsaaWe retrospectively analyzed the clinical data of patients with PD who underwent GPi (n = 14) or STN (n = 28) DBS surgery between April 2002 and May 2014. The subjects were matched for age at surgery and disease duration. The Unified Parkinson’s Disease Rating Scale (UPDRS) scores and levodopa equivalent dose (LED) at baseline and 12 months after surgery were used to assess the therapeutic effects of DBS. Adverse effects were also compared between the two groups.
Results:At 12 months, the mean changes in the UPDRS total and part I–IV scores did not differ significantly between the two groups. However, the subscores for gait disturbance/postural instability and dyskinesia were significantly more improved after GPi DBS than those after STN DBS (p = 0.024 and 0.016, respectively). The LED was significantly more reduced in patients after STN DBS than that after GPi DBS (p = 0.004). Serious adverse effects did not differ between the two groups (p = 0.697).
Conclusion:The patients with PD showed greater improvement in gait disturbance/postural instability and dyskinesia after GPi DBS compared with those after STN DBS, although the patients had a greater reduction in LED after STN DBS. These results may provide useful information for optimal target selection for DBS in PD.
Department
Dept. of Neurology (신경과학)
Publisher
School of Medicine
Citation
Sooyeoun You et al. (2017). Comparison of Pallidal and Subthalamic Deep Brain Stimulation in Parkinson’s Disease: Therapeutic and Adverse Effects. Journal of Movement Disorders, 10(2), 80–86. doi: 10.14802/jmd.17001
Type
Article
ISSN
2005-940X
DOI
10.14802/jmd.17001
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32472
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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