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Prevalence and possible causes of hypouricemia at a tertiary care hospital

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Affiliated Author(s)
김상현김지민손창남
Alternative Author(s)
Kim, Sang HyonKim, Ji MinSon, Chang Nam
Journal Title
Korean Jouranl of Internal Medicine
ISSN
1226-3303
Issued Date
2016
Keyword
HypouricemiaUric acid
Abstract
Background/Aims: We aimed to investigate the prevalence and possible causes of
hypouricemia in the Korean population and to compare our findings with published
results of other populations.
Methods: We examined the serum uric acid levels of 30,757 subjects who had their
uric acid values measured at least once during a 1-year period. All individuals
with hypouricemia (serum uric acid < 2.0 mg/dL, n = 424) were reviewed with respect
to medical drug history and concomitant diseases previously identified as
being associated with hypouricemia.
Results: The prevalence of hypouricemia was 4.14% (299/7,223) among inpatients
and 0.53% (125/23,534) among outpatients, for an overall prevalence of 1.39%
(424/30,757). Possible causes associated with hypouricemia were found to be solid
or hematologic malignancies (n = 86), diabetes mellitus (n = 56), and therapeutic
drugs (n = 29). The medications were allopurinol (n = 11), angiotensin II receptor
blockers (n = 10), salicylates (n = 6), febuxostat (n = 1), and warfarin (n = 1). In the
remaining 226 individuals, the cause of hypouricemia was not identified.
Conclusions: Hypouricemia is relatively common in the Korean population compared
to those of other countries. The possible causes associated with hypouricemia
are related to underlying diseases and medications.
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
Chang-Nam Son et al. (2016). Prevalence and possible causes of hypouricemia at a tertiary care hospital. Korean Jouranl of Internal Medicine, 31(5), 971–976. doi: 10.3904/kjim.2015.125
Type
Article
ISSN
1226-3303
DOI
10.3904/kjim.2015.125
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32500
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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