Prevalence and possible causes of hypouricemia at a tertiary care hospital
- Affiliated Author(s)
- 김상현; 김지민; 손창남
- Alternative Author(s)
- Kim, Sang Hyon; Kim, Ji Min; Son, Chang Nam
- Journal Title
- Korean Jouranl of Internal Medicine
- ISSN
- 1226-3303
- Issued Date
- 2016
- Keyword
- Hypouricemia; Uric acid
- Abstract
- Background/Aims: We aimed to investigate the prevalence and possible causes of
hypouricemia in the Korean population and to compare our findings with published
results of other populations.
Methods: We examined the serum uric acid levels of 30,757 subjects who had their
uric acid values measured at least once during a 1-year period. All individuals
with hypouricemia (serum uric acid < 2.0 mg/dL, n = 424) were reviewed with respect
to medical drug history and concomitant diseases previously identified as
being associated with hypouricemia.
Results: The prevalence of hypouricemia was 4.14% (299/7,223) among inpatients
and 0.53% (125/23,534) among outpatients, for an overall prevalence of 1.39%
(424/30,757). Possible causes associated with hypouricemia were found to be solid
or hematologic malignancies (n = 86), diabetes mellitus (n = 56), and therapeutic
drugs (n = 29). The medications were allopurinol (n = 11), angiotensin II receptor
blockers (n = 10), salicylates (n = 6), febuxostat (n = 1), and warfarin (n = 1). In the
remaining 226 individuals, the cause of hypouricemia was not identified.
Conclusions: Hypouricemia is relatively common in the Korean population compared
to those of other countries. The possible causes associated with hypouricemia
are related to underlying diseases and medications.
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