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Diagnostic accuracy of 18F-FDG PET/CT for detecting synchronous advanced colorectal neoplasia in patients with gastric cancer

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Affiliated Author(s)
김해원조광범원경숙송봉일배성욱
Alternative Author(s)
Kim, Hae WonWon, Kyoung SookSong, Bong IlCho, Kwang BumBae, Sung Uk
Journal Title
Medicine
ISSN
0025-7974
Issued Date
2016
Keyword
gastric cancerpositron emission tomographysensitivityspecificitysynchronous colorectal cancer
Abstract
Preoperative screening for synchronous colorectal neoplasia (CRN) has been recommended in patients with gastric cancer because patients with gastric cancer are at increased risk for synchronous CRN. The aim of this study was to investigate the diagnostic accuracy of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) for detecting synchronous advanced CRN in patients with gastric cancer.

A total of 256 patients who underwent colonoscopy and 18F-FDG PET/CT for preoperative staging were enrolled in this study. The diagnosis of focal colonic 18F-FDG uptake on 18F-FDG PET/CT image was made based on histopathologic results from the colonoscopic biopsy. The 18F-FDG PET/CT result was considered as true positive for advanced CRN when focal 18F-FDG uptake matched colorectal carcinoma or adenoma with high-grade dysplasia in the same location on colonoscopy.

Synchronous advanced CRN was detected in 21 of the 256 patients (4.7%). Sensitivity, specificity, and accuracy of 18F-FDG PET/CT were 76.2%, 96.2%, and 94.5%. The size of CRN with a true positive result was significantly larger than that with a false negative result.

18F-FDG PET/CT demonstrated high diagnostic accuracy for detecting synchronous advanced CRN in patients with gastric cancer. Colonoscopy is recommended as the next diagnostic step for further evaluation of a positive 18F-FDG PET/CT result in patients with gastric cancer.
Department
Dept. of Nuclear Medicine (핵의학)
Dept. of Internal Medicine (내과학)
Dept. of Surgery (외과학)
Publisher
School of Medicine
Citation
Byung Wook Choi et al. (2016). Diagnostic accuracy of 18F-FDG PET/CT for detecting synchronous advanced colorectal neoplasia in patients with gastric cancer. Medicine, 95(36), e4741–e4741. doi: 10.1097/MD.0000000000004741
Type
Article
ISSN
0025-7974
DOI
10.1097/MD.0000000000004741
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32518
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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