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Diabetes mellitus increases the risk of intrahepatic recurrence of hepatocellular carcinoma after surgical resection

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Affiliated Author(s)
이윤한
Alternative Author(s)
Lee, Yun Han
Journal Title
Tumori
ISSN
0300-8916
Issued Date
2017
Keyword
Diabetes mellitusHepatocellular carcinomaHepatitis B
Abstract
Aims and background;The relationship between cancer and metabolism has recently been receiving attention. We investigated the prognostic influence of type 2 diabetes mellitus in patients with hepatocellular carcinoma (HCC) treated with curative resection.
Methods and Study Design;
The records of 58 patients who underwent curative resection for HCC pT1-2N0M0 between 2010 and 2014 were reviewed retrospectively. Fourteen patients (24.1%) had diabetes mellitus at diagnosis. Local control (LC) was defined as time to recurrence in the liver.
Results;


The median follow-up was 23.3 months. Relapses occurred in 20 patients (34.5%) during the follow-up period; 17 of them developed intrahepatic recurrence, which was associated with diabetes mellitus (p = 0.013) and alpha fetoprotein (AFP) levels >500 ng/mL (p = 0.019). Overall relapses (n = 20) were related to T stage (p = 0.044), AFP level (p = 0.005), and diabetes (p = 0.044). The 3-year local control (intrahepatic control), disease-free survival, and overall survival rates were 56.7%, 50.5%, and 84.3%, respectively. LC was affected by diabetes mellitus (p = 0.046), Barcelona Clinic Liver Cancer staging (p<0.001), Milan criteria for transplantation (p = 0.041), serosal invasion (p = 0.032), and microvascular invasion (p = 0.043). Diabetes was also associated with reduced LC in the subgroup with hepatitis B-related HCC (n = 44, p = 0.028).



Conclusions;


Diabetes mellitus is correlated with intrahepatic HCC recurrence after surgery. Greater attention should be paid to managing patients with HCC and diabetes mellitus.
Department
Dept. of Molecular Medicine (분자의학)
Publisher
School of Medicine
Citation
Yunseon Choi et al. (2017). Diabetes mellitus increases the risk of intrahepatic recurrence of hepatocellular carcinoma after surgical resection. Tumori, 103(3), 279–285. doi: 10.5301/tj.5000594
Type
Article
ISSN
0300-8916
DOI
10.5301/tj.5000594
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32581
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Molecular Medicine (분자의학)
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