쯔쯔가무시병에 동반된 폐색전증 1예

Abstract

Acute pulmonary embolism is a cardiovascular emergency and is a major cause of morbidity and mortality. Endothelial damage secondary to invasion by Orientia tsutsugamushi can lead to focal occlusive endangiitis, causing microinfarcts in various tissues. This localized process can also cause venous thrombosis and peripheral gangrene. However, pulmonary embolism associated with scrub typhus has not been reported in Korea. Here, we report a patient diagnosed with pulmonary embolism associated with scrub typhus, the first report of its kind. The patient had an eschar with detection of anti-tsutsugamushi antibody, fever, dyspnea, and a maculopapular rash over the entire body. He was treated with doxycycline and anticoagulation therapy.

O.tsutsugamushi는 혈관내피세포를 침투하여 혈관 주위염과 혈관내피 손상을 일으키면서 혈전증을 유발할 수도 있다. 저자들은 과거력 및 가족력상 정맥 혈전색전증 발생의 위험인자가 없는 쯔쯔가무시병 환자에서 폐색전증이 발생한 45세 남자 환자를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.