Predictive risk factors for L. monocytogenes meningitis compared to pneumococcal meningitis: a multicenter case-control study
- Affiliated Author(s)
- 류성열; 김현아
- Alternative Author(s)
- Ryu, Seong Yeol; Kim, Hyun Ah
- Journal Title
- Infection
- ISSN
- 0300-8126
- Issued Date
- 2017
- Keyword
- Immunocompromised host; Liver diseases; Elderly Streptococcus pneumoniae; Listeriosis
- Abstract
- Purpose Various immunocompromised conditions increase
the risk of meningitis caused by Listeria monocytogenes.
However, the relative importance of these risk factors has
not been well established. We determined the risk factors
that predict meningitis due to L. monocytogenes compared
to that caused by Streptococcus pneumoniae.
Methods A nationwide multicenter case–control study
was conducted in Korea. Cases of meningitis caused by
L. monocytogenes between 1998 and 2013 were included.
Patients with pneumococcal meningitis were included as controls. Multivariate logistic regression analysis was used
to predict the risk factors of Listeria meningitis.
Results A total of 36 cases and 113 controls were enrolled.
The most significant predictive risk factor of Listeria meningitis
was a prior history of receiving immunosuppressive
therapy (odds ratio 8.12, 95 % CI 2.47–26.69). Chronic
liver disease was the second most important predictive risk
factor (OR 5.03, 95 % CI 1.56–16.22). Delaying appropriate
antibiotic therapy by more than 6 h (hazard ratio 2.78)
and fatal underlying disease (hazard ratio 2.88) were associated
with increased mortality.
- 공개 및 라이선스
-
- 파일 목록
-
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.