Association between perfluorooctanoic acid exposure and degranulation of mast cells in allergic inflammation

Authors
Jun‐Kyoung LeeSoyoung LeeMoon‐Chang BaekByung‐Heon LeeHyun‐Shik LeeTaeg Kyu KwonPil‐Hoon ParkTae‐Yong ShinDongwoo KhangSang‐Hyun Kim
Department
Dept. of Immunology (면역학)
Issue Date
2017
Citation
Journal of Applied Toxicology, Vol.37(5) : 554-562, 2017
ISSN
0260-437X
Abstract
Perfluorooctanoic acid (PFOA) has wide applications, including as a raw material for converted paper and packaging products. With the widespread use of PFOA, concerns regarding its potential environmental and health impacts have increased. In spite of the known hepatotoxicity and genotoxicity of PFOA, correlation with PFOA and allergic inflammation is not well known. In this study, the effect of PFOA on the degranulation of mast cells and mast cell‐mediated allergic inflammation in the presence of FcεRI cross‐linking was evaluated. In immunoglobulin (Ig) E‐stimulated mast cells, PFOA increased the release of histamine and β‐hexosaminidase by the up‐regulation of intracellular calcium levels. PFOA enhanced gene expression of several pro‐inflammatory cytokines, including tumor necrosis factor (TNF)‐α, interleukin (IL)‐1β, IL‐6, and IL‐8 by the activation of nuclear factor (NF)‐κB in IgE‐stimulated mast cells. Also, PFOA exacerbated allergic symptoms via hypothermia, and an increase of serum histamine, TNF‐α, IgE and IgG1 in the ovalbumin‐induced systemic anaphylaxis. The present data indicate that PFOA aggravated FcɛRI‐mediated mast cell degranulation and allergic symptoms.
Keywords
perfluorooctanoic acid (PFOA)allergic inflammationmast cellshistaminepro-inflammatory cytokine
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/32789
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
Keimyung Author(s)
권택규
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1002/jat.3389
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