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Effects of topical ketorolac tromethamine 0.45% on intraoperative miosis and prostaglandin E2 release during femtosecond laser-assisted cataract surgery.

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Affiliated Author(s)
전종화
Alternative Author(s)
Jun, Jong Hwa
Journal Title
Journal of Cataract & Refractive Surgery
ISSN
0886-3350
Issued Date
2017
Abstract
Purpose: To determine the effects of topical 0.45% ketorolac
tromethamine on intraoperative miosis and prostaglandin E2
(PGE2) release during femtosecond laser–assisted cataract surgery.
Setting: Seoul St. Mary's Hospital, Seoul, Korea.
Design: Prospective case series.
Methods: The study comprised the following 3 groups: conventional
cataract surgery without topical NSAIDs (conventional group);
femtosecond laser–assisted cataract surgery with preoperative
topical ketorolac tromethamine 0.45%(femtosecond NSAID group),
and femtosecond laser–assisted cataract surgery without topical
NSAIDs (femtosecond no-NSAID group). To measure the aqueous
humor PGE2 concentration, a 100 mL aqueous humor sample was
collected from the anterior chamber after femtosecond laser
pretreatment. The PGE2 concentration was measured using an
enzyme immunoassay. Results: Topical ketorolac tromethamine 0.45%led to a significant
reduction in intraoperative miosis in the femtosecond NSAID group
compared with the femtosecond no-NSAID group (P < .001).
Absolute and relative reductions in pupil area in the femtosecond
NSAID group were significantly lower than in the femtosecond
no-NSAID group (P Z .019 and P Z .007, respectively). The mean
aqueous humor PGE2 concentrations were 893.60 pg/mL G
843.10 (SD) in the conventional group, 1911.43 G 1178.63 pg/mL
in the femtosecond NSAID group, and 743.63 G 927.46 pg/mL in
the femtosecond no-NSAID group (P < .001, conventional versus
femtosecond NSAID and femtosecond NSAID versus femtosecond
no NSAID; P > .05, conventional versus femtosecond NSAID).
Conclusion: Preoperative topical ketorolac tromethamine 0.45%
reduced miosis induced by femtosecond laser pretreatment and
inhibited aqueous humor PGE2 elevation.
Department
Dept. of Ophthalmology (안과학)
Publisher
School of Medicine
Citation
Jong Hwa Jun et al. (2017). Effects of topical ketorolac tromethamine 0.45% on intraoperative miosis and prostaglandin E2 release during femtosecond laser-assisted cataract surgery. Journal of Cataract & Refractive Surgery, 43(4), 492–497. doi: 10.1016/j.jcrs.2017.01.011
Type
Article
ISSN
0886-3350
DOI
10.1016/j.jcrs.2017.01.011
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32791
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Ophthalmology (안과학)
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