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Comparison of Outcomes After Percutaneous Coronary Intervention for Chronic Total Occlusion Using Everolimus- Versus Sirolimus- Versus Paclitaxel-Eluting Stents (from the Korean National Registry of Chronic Total Occlusion Intervention)

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Affiliated Author(s)
허승호
Alternative Author(s)
Hur, Seung Ho
Journal Title
American Journal of Cardiology.
ISSN
0002-9149
Issued Date
2015
Abstract
For the treatment of chronic total occlusion (CTO), the efficacy and safety of the everolimuseluting
stent (EES) remain less well defined. Also, there are limited data for the predictors of
outcome after CTO intervention. The purpose of this study was to compare clinical outcomes
of the EES with the first-generation drug-eluting stent (DES) in CTO intervention and to
investigate the predictors of clinical outcome. The Korean National Registry of CTO
Intervention is a retrospective cohort of 26 centers from the past 5 years. The primary end
point was major adverse cardiovascular events (MACE) defined as a composite of cardiac
death, nonfatal myocardial infarction, and target lesion revascularization. Of the 1,754
all-comer patients, 1,509 patients (EES 311, sirolimus-eluting stent [SES] 642, paclitaxeleluting
stent 556) were finally analyzed after excluding 245 patients (mixed DESs in 46
and follow-up loss in 199). In the inverse probability weightingeadjusted population, the
1-yearMACE rate of the EES was comparable with that of the SES (5.8% vs 3.4%, p[0.796)
and the paclitaxel-eluting stent (5.8% vs 6.9%, p [ 0.740). Each component of MACE was
also comparable among the 3 stents. Importantly, the independent predictors of MACE were
diabetes mellitus, previous congestive heart failure, and left circumflex CTO. In conclusion,
for the first time in the largest CTO cohort, the EES showed good 1-year clinical outcomes
that were comparable with the SES. Independent predictors of MACE after CTO intervention
were clinical factors (diabetes and congestive heart failure) and lesion
location.
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
Min-Ho Lee et al. (2015). Comparison of Outcomes After Percutaneous Coronary Intervention for Chronic Total Occlusion Using Everolimus- Versus Sirolimus- Versus Paclitaxel-Eluting Stents (from the Korean National Registry of Chronic Total Occlusion Intervention). American Journal of Cardiology., 116(2), 195–203. doi: 10.1016/j.amjcard.2015.04.010
Type
Article
ISSN
0002-9149
DOI
10.1016/j.amjcard.2015.04.010
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32920
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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