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Dicer Is Down-regulated and Correlated with Drosha in Idiopathic Sudden Sensorineural Hearing Loss

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Affiliated Author(s)
김신이재호남성일
Alternative Author(s)
Kim, ShinLee, Jae HoNam, Sung Il
Journal Title
Journal of Korean Medical Science
ISSN
1011-8934
Issued Date
2015
Keyword
MicroRNA BiogenesisIdiopathic Sudden Sensorineural Hearing LossDicerDrosha
Abstract
Previously, we reported the expression levels of specific microRNA machinery components,
DGCR8 and AGO2, and their clinical association in patients with idiopathic sudden hearing
loss (SSNHL). In the present study, we investigated the other important components of
microRNA machinery and their association with clinical parameters in SSNHL patients.
Fifty-seven patients diagnosed with SSNHL and fifty healthy volunteers were included in
this study. We evaluated mRNA expression levels of Dicer and Drosha in whole blood of
patients with SSNHL and the control group, using RT & real-time PCR analysis. The Dicer
mRNA expression level was down-regulated in patients with SSNHL. However, the Drosha
mRNA expression level was not significantly altered in patients with SSNHL. Neither the
Dicer nor Drosha mRNA expression level was not associated with any clinical parameters,
including age, sex, duration of initial treatment from onset (days), initial Pure tone
average, Siegel’s criteria, WBC, and Erythrocyte sedimentation rate. However, mRNA
expression levels of Dicer and Drosha were positively correlated to each other in patients
with SSNHL. In this study, we demonstrated for the first time that the Dicer mRNA
expression level was down-regulated in patients with SSNHL, suggesting its important role
in pathobiology of SSNHL development.
Keywords: MicroRNA Biogenesis; Idiopathic Sudden Sensorineural Hearing Loss; Dicer;
Drosha
Department
Dept. of Immunology (면역학)
Dept. of Anatomy (해부학)
Dept. of Otorhinolaryngology (이비인후과학)
Publisher
School of Medicine
Citation
Shin Kim et al. (2015). Dicer Is Down-regulated and Correlated with Drosha in Idiopathic Sudden Sensorineural Hearing Loss. Journal of Korean Medical Science, 30(8), 1183–1188. doi: 10.3346/jkms.2015.30.8.1183
Type
Article
ISSN
1011-8934
DOI
10.3346/jkms.2015.30.8.1183
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32938
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
1. School of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학)
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