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In Vitro Activities of 21 Antimicrobial Agents Alone and in Combination with Aminoglycosides or Fluoroquinolones against Extended-Spectrum-β-Lactamase-Producing Escherichia coli Isolates Causing Bacteremia

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Affiliated Author(s)
류성열김현아
Alternative Author(s)
Ryu, Seong YeolKim, Hyun Ah
Journal Title
Antimicrobial Agents and Chemotherapy
ISSN
0066-4804
Issued Date
2015
Abstract
We evaluated the in vitro activity of various antimicrobials alone and in combination against 291 extended-spectrum- -lactamase-
producing Escherichia coli (ESBL-EC) isolates causing bacteremia in South Korean hospitals. Ceftazidime, cefepime, and
piperacillin-tazobactam in combination with amikacin showed greater activity than found in combination with ciprofloxacin. In
settings with a high prevalence of ESBL-producing pathogens, combination aminoglycoside antimicrobial therapy, especially
with amikacin, may be considered for empirical therapy against suspected Gram-negative sepsis as a carbapenem-saving
strategy.
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
Min Kyeong Cha et al. (2015). In Vitro Activities of 21 Antimicrobial Agents Alone and in Combination with Aminoglycosides or Fluoroquinolones against Extended-Spectrum-β-Lactamase-Producing Escherichia coli Isolates Causing Bacteremia. Antimicrobial Agents and Chemotherapy, 59(9), 5834 –5837–5834 –5837. doi: 10.1128/AAC.01121-15
Type
Article
ISSN
0066-4804
DOI
10.1128/AAC.01121-15
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32978
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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