In Vitro Activities of 21 Antimicrobial Agents Alone and in Combination with Aminoglycosides or Fluoroquinolones against Extended-Spectrum-β-Lactamase-Producing Escherichia coli Isolates Causing Bacteremia
- Affiliated Author(s)
- 류성열; 김현아
- Alternative Author(s)
- Ryu, Seong Yeol; Kim, Hyun Ah
- Journal Title
- Antimicrobial Agents and Chemotherapy
- ISSN
- 0066-4804
- Issued Date
- 2015
- Abstract
- We evaluated the in vitro activity of various antimicrobials alone and in combination against 291 extended-spectrum- -lactamase-
producing Escherichia coli (ESBL-EC) isolates causing bacteremia in South Korean hospitals. Ceftazidime, cefepime, and
piperacillin-tazobactam in combination with amikacin showed greater activity than found in combination with ciprofloxacin. In
settings with a high prevalence of ESBL-producing pathogens, combination aminoglycoside antimicrobial therapy, especially
with amikacin, may be considered for empirical therapy against suspected Gram-negative sepsis as a carbapenem-saving
strategy.
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