계명대학교 의학도서관 Repository

Treatment with a Small Synthetic Compound, KMU-193, induces Apoptosis in A549 Human Lung Carcinoma Cells through p53 Up-Regulation.

Metadata Downloads
Affiliated Author(s)
권택규김신박종욱
Alternative Author(s)
Kwon, Taeg KyuKim, ShinPark, Jong Wook
Journal Title
Asian Pacific Journal of Cancer Prevention
ISSN
1513-7368
Issued Date
2015
Keyword
KMU-193Lung cancerApoptosisCaspasep53
Abstract
Despite recent advances in therapeutic strategies for lung cancer, mortality still is increasing. In the present
study, we investigated the anti-cancer effects of KMU-193, 2-(4-Ethoxy-phenyl)-N-{5-[2-fluoro-4-(4-methylpiperazine-
1-carbonyl)-phenylamino]-1H-indazol-3-yl}-acetamide in a human non-small cell lung cancer cell line
A549. KMU-193 strongly inhibited the proliferation of A549 cells, but it did not have anti-proliferative effect in
other types of cancer cell lines. KMU-193 further induced apoptosis in association with activation of caspase-3
and cleavage of PLC-γ1. However, KMU-193 had no apoptotic effect in untransformed cells such as TMCK-1
and BEAS-2B. Interestingly, pretreatment with z-VAD-fmk, a pan-caspase inhibitor, strongly abrogated KMU-
193-induced apoptosis. KMU-193 treatment enhanced the expression levels of p53 and PUMA. Importantly,
p53 siRNA transfection attenuated KMU-193-induced apoptosis. Collectively, these results for the first time
demonstrate that KMU-193 has strong apoptotic effects on A549 cells and these are largely mediated through
caspase-3- and p53-dependent pathways.
Department
Dept. of Immunology (면역학)
Publisher
School of Medicine
Citation
Eun Young Choi et al. (2015). Treatment with a Small Synthetic Compound, KMU-193, induces Apoptosis in A549 Human Lung Carcinoma Cells through p53 Up-Regulation. Asian Pacific Journal of Cancer Prevention, 16(14), 5883–5887. doi: 10.7314/APJCP.2015.16.14.5883
Type
Article
ISSN
1513-7368
DOI
10.7314/APJCP.2015.16.14.5883
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33073
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.