Clinical recommendations for defining platinum unsuitable head and neck cancer patient populations on chemoradiotherapy: A literature review
- Affiliated Author(s)
- 박건욱
- Alternative Author(s)
- Park, Keon Uk
- Journal Title
- Oral Oncology
- ISSN
- 1368-8375
- Issued Date
- 2016
- Keyword
- Cisplatin; Chemoradiotherapy; Criteria; Expert opinion; Head and neck cancer; Patients; Toxicity; Unsuitability
- Abstract
- Toxicities resulting from platinum based chemotherapy in head and neck cancer is a cause for much
concern. There is a lack of clinical criteria for defining these patient populations, which has posed serious
problems associated with increased morbidity and consequently an adverse effect on patients’ quality of
life. In addition, there is a lack of consensus on clinical criteria for defining such patient populations, who
may be unsuitable for concurrent chemoradiotherapy. A group of experts in the field of head and neck
cancer from the Asia Pacific Region convened in August 2014 in Korea to discuss the development of a
set of clinical criteria in order to fill the knowledge gap and provide a reference tool for head and neck
oncologists. This paper reports the final output from this meeting and the accompanying literature
review, with the aim of aiding clinical decision making with the help of some clinical criteria to identify
platinum unsuitable patient populations in head and neck cancer management. Some alternative treatment
options are also discussed in this paper.
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