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Association between obesity and local control of advanced rectal cancer after combined surgery and radiotherapy

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Affiliated Author(s)
이윤한
Alternative Author(s)
Lee, Yun Han
Journal Title
Radiation Oncology Journal
ISSN
2234-1900
Issued Date
2016
Keyword
ObesityRectal cancerRadiotherapyLocal controlPrognosis
Abstract
Purpose: The association between metabolism and cancer has been recently emphasized. This study aimed to find the prognostic
significance of obesity in advanced stage rectal cancer patients treated with surgery and radiotherapy (RT).
Materials and Methods: We retrospectively reviewed the medical records of 111 patients who were treated with combined
surgery and RT for clinical stage 2–3 (T3 or N+) rectal cancer between 2008 and 2014. The prognostic significance of obesity (body
mass index [BMI] ≥25 kg/m2) in local control was evaluated.
Results: The median follow-up was 31.2 months (range, 4.1 to 85.7 months). Twenty-five patients (22.5%) were classified as obese.
Treatment failure occurred in 33 patients (29.7%), including local failures in 13 patients (11.7%), regional lymph node failures in 5,
and distant metastases in 24. The 3-year local control, recurrence-free survival, and overall survival rates were 88.7%, 73.6%, and
87.7%, respectively. Obesity (n = 25) significantly reduced the local control rate (p = 0.045; 3-year local control, 76.2%), especially
in women (n = 37, p = 0.021). Segregation of local control was best achieved by BMI of 25.6 kg/m2 as a cutoff value.
Conclusion: Obese rectal cancer patients showed poor local control after combined surgery and RT. More effective local treatment
strategies for obese patients are warranted.
Department
Dept. of Molecular Medicine (분자의학)
Publisher
School of Medicine
Citation
Yunseon Choi et al. (2016). Association between obesity and local control of advanced rectal cancer after combined surgery and radiotherapy. Radiation Oncology Journal, 34(2), 113–120. doi: 10.3857/roj.2016.01725
Type
Article
ISSN
2234-1900
DOI
10.3857/roj.2016.01725
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33137
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Molecular Medicine (분자의학)
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