Clinical significance of melanoma-associated antigen A1-6 expression in sputum of patients with squamous cell carcinoma of the larynx and hypopharynx
- Alternative Author(s)
- Park, Jong Wook
- Publication Year
- Squamous cell carcinoma; Larynx; Hypopharynx; Head and neck cancer; Melanoma-associated antigen (MAGE)
- Background. Several studies have reported the expression
of the melanoma-associated antigen (MAGE) gene in head and neck
squamous cell carcinoma (HNSCC). In this study, we evaluated the cor-
relations between MAGE expression in sputum and the clinical features
and oncologic outcomes of SCC of the larynx and hypopharynx.
Methods. We performed a retrospective review of 119 patients treated
for SCC of the larynx and hypopharynx and analysis of their induced spu-
tum by nested reverse transcription-polymerase chain reaction (RT-PCR)
to detect the MAGE-A1–6 gene. The associations between MAGE
expression and clinical characteristics were analyzed.
Results. Expression of MAGE-A1–6 in sputum was identified in 57 of
119 patients (47.9%), and was independently correlated to double
primary cancer (p 5 .024; odds ratio [OR] 5 4.135). Expression of
MAGE-A1–6 in sputum was correlated to poor survival.
Conclusion. Expression of MAGE-A1–6 in sputum predicts poor oncologic
outcome in patients with SCC of the larynx and hypopharynx.
Wiley Periodicals, Inc. Head Neck 38: E736–E740, 2016
KEY WORDS: squamous cell carcinoma, larynx, hypopharynx, head
and neck cancer, melanoma-associated antigen (MAGE)
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