계명대학교 의학도서관 Repository

Corosolic acid ameliorates acute inflammation through inhibition of IRAK-1 phosphorylation in macrophages

Metadata Downloads
Affiliated Author(s)
박재형배재훈송대규임승순
Alternative Author(s)
Park, Jae HyungBae, Jae HoonSong, Dae KyuIm, Seung Soon
Journal Title
BMB Reports
ISSN
1976-670X
Issued Date
2016
Keyword
Acute inflammationCorosolic acidInflammasomeIRAK-1Macrophages
Abstract
Lagerstroemia speciosa L. (Banaba) leaves, exerts anti-inflammatory
effects by regulating phosphorylation of interleukin receptor-
associated kinase (IRAK)-2 via the NF-B cascade.
However, the protective effect of CA against endotoxic shock
has not been reported. LPS (200 ng/mL, 30 min) induced phosphorylation
of IRAK-1 and treatment with CA (10 M) significantly
attenuated this effect. In addition, CA also reduced
protein levels of NLRP3 and ASC which are the main components
of the inflammasome in BMDMs. LPS-induced inflammasome
assembly through activation of IRAK-1 was down-regulated
by CA challenge. Treatment with Bay11-7082, an inhibitor
of IB-, had no effect on CA-mediated inhibition of
IRAK-1 activation, indicating that CA-mediated attenuation of
IRAK-1 phosphorylation was independent of NF-B signaling.
These results demonstrate that CA ameliorates acute inflammation
in mouse BMDMs and CA may be useful as a pharmacological
agent to prevent acute inflammation.
Department
Dept. of Physiology (생리학)
Publisher
School of Medicine
Citation
Seung-Jae Kim et al. (2016). Corosolic acid ameliorates acute inflammation through inhibition of IRAK-1 phosphorylation in macrophages. BMB Reports, 49(5), 276–281. doi: 10.5483/BMBRep.2016.49.5.241
Type
Article
ISSN
1976-670X
DOI
10.5483/BMBRep.2016.49.5.241
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33174
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.