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Corosolic acid ameliorates acute inflammation through inhibition of IRAK-1 phosphorylation in macrophages

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Affiliated Author(s)
박재형배재훈송대규임승순
Alternative Author(s)
Park, Jae HyungBae, Jae HoonSong, Dae KyuIm, Seung Soon
Journal Title
BMB Reports
ISSN
1976-670X
Issued Date
2016
Keyword
Acute inflammationCorosolic acidInflammasomeIRAK-1Macrophages
Abstract
Lagerstroemia speciosa L. (Banaba) leaves, exerts anti-inflammatory
effects by regulating phosphorylation of interleukin receptor-
associated kinase (IRAK)-2 via the NF-B cascade.
However, the protective effect of CA against endotoxic shock
has not been reported. LPS (200 ng/mL, 30 min) induced phosphorylation
of IRAK-1 and treatment with CA (10 M) significantly
attenuated this effect. In addition, CA also reduced
protein levels of NLRP3 and ASC which are the main components
of the inflammasome in BMDMs. LPS-induced inflammasome
assembly through activation of IRAK-1 was down-regulated
by CA challenge. Treatment with Bay11-7082, an inhibitor
of IB-, had no effect on CA-mediated inhibition of
IRAK-1 activation, indicating that CA-mediated attenuation of
IRAK-1 phosphorylation was independent of NF-B signaling.
These results demonstrate that CA ameliorates acute inflammation
in mouse BMDMs and CA may be useful as a pharmacological
agent to prevent acute inflammation.
Department
Dept. of Physiology (생리학)
Publisher
School of Medicine
Citation
BMB Reports, Vol.49(5) : 276-281, 2016
Type
Article
DOI
10.5483/BMBRep.2016.49.5.241
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/33174
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
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