Corosolic acid ameliorates acute inflammation through inhibition of IRAK-1 phosphorylation in macrophages
- Affiliated Author(s)
- 박재형; 배재훈; 송대규; 임승순
- Alternative Author(s)
- Park, Jae Hyung; Bae, Jae Hoon; Song, Dae Kyu; Im, Seung Soon
- Journal Title
- BMB Reports
- Issued Date
- Acute inflammation; Corosolic acid; Inflammasome; IRAK-1; Macrophages
- Lagerstroemia speciosa L. (Banaba) leaves, exerts anti-inflammatory
effects by regulating phosphorylation of interleukin receptor-
associated kinase (IRAK)-2 via the NF-B cascade.
However, the protective effect of CA against endotoxic shock
has not been reported. LPS (200 ng/mL, 30 min) induced phosphorylation
of IRAK-1 and treatment with CA (10 M) significantly
attenuated this effect. In addition, CA also reduced
protein levels of NLRP3 and ASC which are the main components
of the inflammasome in BMDMs. LPS-induced inflammasome
assembly through activation of IRAK-1 was down-regulated
by CA challenge. Treatment with Bay11-7082, an inhibitor
of IB-, had no effect on CA-mediated inhibition of
IRAK-1 activation, indicating that CA-mediated attenuation of
IRAK-1 phosphorylation was independent of NF-B signaling.
These results demonstrate that CA ameliorates acute inflammation
in mouse BMDMs and CA may be useful as a pharmacological
agent to prevent acute inflammation.
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