계명대학교 의학도서관 Repository

Insulin and glucagon levels of umbilical cord blood in appropriate for gestational age - preterm infants with or without postnatal hypoglycemia

Metadata Downloads
Affiliated Author(s)
박재현김천수이상락김흥식배진곤김신
Alternative Author(s)
Park, Jae HyunKim, Chun SooLee, Sang LakKim, Heung SikBae, Jin GonKim, Shin
Journal Title
Annals of Pediatric Endocrinology & Metabolism.
ISSN
2287-1012
Issued Date
2016
Keyword
InsulinGlucagonFetal bloodHypoglycemiaPremature infant
Abstract
Purpose: To determine whether serum insulin and glucagon levels of umbilical
cord blood correlate with subsequent postnatal hypoglycemia in appropriate for
gestational age (AGA) – preterm infants at different gestational ages (GAs).
Methods: The serum insulin and glucagon levels of umbilical cord blood were
measured using magnetic bead based multiplex immunoassay in 69 AGA -
premature infants, stratified according to GA: GA 23–30 weeks, early preterm
(EP, n=31); GA 31–34 weeks, late preterm (LP, n=38). Postnatal hypoglycemia was
defined as a capillary glucose level <40 mg/dL within the first 60 minutes of life,
regardless of GA.
Results: The capillary glucose concentration in EP infants (65.5±21.2 mg/dL) was
significantly higher than that of LP infants (55.9±17.3 mg/dL) (P=0.043). The serum
glucagon level in EP infants (44.3±28.7 pg/mL) was significantly higher than that
in LP infants (28.1±13.6 pg/mL) (P=0.006). There was not a significant difference in
serum insulin level between EP and LP infants (372.7±254.2 pg/mL vs. 372.4±209.1
pg/mL, P=0.996). There was a significant difference in the serum glucagon level
between infants with and without hypoglycemia (27.7±8.9 mg/dL vs. 36.8±
24.6 mg/dL, P=0.036), but not in the serum insulin level (451.9±256.9 pg/mL vs.
357.4±222.2 pg/mL, P=0.211). Postnatal glucose concentration within the first 60
minutes of life had a significant positive correlation with serum glucagon levels
(r=0.256, P=0.034), but not with serum insulin levels (r=–0.020, P=0.867).
Conclusion: Lower glucagon levels of cord blood were seen in premature
infants with higher GA, which might contribute to the occurrence of postnatal
hypoglycemia.
Keywords: Insulin, Glucagon, Fetal blood, Hypoglycemia, Premature infant
Department
Dept. of Pediatrics (소아청소년학)
Dept. of Obstetrics & Gynecology (산부인과학)
Dept. of Immunology (면역학)
Publisher
School of Medicine
Citation
Jin Gon Bae et al. (2016). Insulin and glucagon levels of umbilical cord blood in appropriate for gestational age - preterm infants with or without postnatal hypoglycemia. Annals of Pediatric Endocrinology & Metabolism., 21(2), 86–91. doi: 10.6065/apem.2016.21.2.86
Type
Article
ISSN
2287-1012
DOI
10.6065/apem.2016.21.2.86
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33222
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.