No association of the rs17822931 polymorphism in ABCC11 with breast cancer risk in Koreans
- Affiliated Author(s)
- 김윤년; 이종하; 김대광
- Alternative Author(s)
- Kim, Yoon Nyun; Lee, Jong Ha; Kim, Dae Kwang
- Journal Title
- Journal of Neurolinguistics
- ISSN
- 0911-6044
- Issued Date
- 2016
- Keyword
- ABCC11; Breast cancer susceptibility; Single nucleotide polymorphism (SNP); Koreans
- Abstract
- ABCC11 is reported to be associated with breast cancer. However, whether ABCC11 polymorphisms relate
to breast cancer risk remains unclear. This study aimed to evaluate any association of a single nucleotide
polymorphism (SNP), rs17822931, in ABCC11 with breast cancer in Koreans. Genomic DNA samples of 170
women with breast cancer and 100 controls were assessed for SNP rs17822931 of ABCC11 by single-strand
conformation polymorphism (SSCP) and DNA sequencing. A 27-bp deletion (Δ27) of ABCC11 was analyzed by
PCR amplification. The genotype of SNP rs17822931 was confirmed to be AA in all samples from breast cancer
patients and Δ27 was found in none of the samples. Our finding indicated that the SNP rs17822931 in ABCC11 is
not associated with breast cancer. However, this study does provide information on fundamental genetic aspects
of ABCC11 with regard to breast cancer risk in Koreans.
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