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No association of the rs17822931 polymorphism in ABCC11 with breast cancer risk in Koreans

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Affiliated Author(s)
김윤년이종하김대광
Alternative Author(s)
Kim, Yoon NyunLee, Jong HaKim, Dae Kwang
Journal Title
Journal of Neurolinguistics
ISSN
0911-6044
Issued Date
2016
Keyword
ABCC11Breast cancer susceptibilitySingle nucleotide polymorphism (SNP)Koreans
Abstract
ABCC11 is reported to be associated with breast cancer. However, whether ABCC11 polymorphisms relate
to breast cancer risk remains unclear. This study aimed to evaluate any association of a single nucleotide
polymorphism (SNP), rs17822931, in ABCC11 with breast cancer in Koreans. Genomic DNA samples of 170
women with breast cancer and 100 controls were assessed for SNP rs17822931 of ABCC11 by single-strand
conformation polymorphism (SSCP) and DNA sequencing. A 27-bp deletion (Δ27) of ABCC11 was analyzed by
PCR amplification. The genotype of SNP rs17822931 was confirmed to be AA in all samples from breast cancer
patients and Δ27 was found in none of the samples. Our finding indicated that the SNP rs17822931 in ABCC11 is
not associated with breast cancer. However, this study does provide information on fundamental genetic aspects
of ABCC11 with regard to breast cancer risk in Koreans.
Department
Dept. of Internal Medicine (내과학)
Dept. of Biomedical Engineering (의용공학과)
Dept. of Medical Genetics (의학유전학)
Publisher
School of Medicine
Citation
Ann-Yae Na et al. (2016). No association of the rs17822931 polymorphism in ABCC11 with breast cancer risk in Koreans. Journal of Neurolinguistics, 17(5), 2625–2628.
Type
Article
ISSN
0911-6044
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33244
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biomedical Engineering (의용공학과)
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Medical Genetics (의학유전학)
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