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TERT promoter mutation, telomere length, and TERT expression in gastric cancer

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Affiliated Author(s)
이현수최인장이재호
Alternative Author(s)
Lee, Hyun SuChoi, In JangLee, Jae Ho
Journal Title
International Journal of Clinical and Experimental Pathology
ISSN
1936-2625
Issued Date
2016
Keyword
Gastric cancerTelomereTERT promoter mutationSurvival curve
Abstract
Objective: The mutation in the promoter region of telomerase reverse transcriptase (TERT) has been focused
in various cancers. In present study, the frequency and clinical characteristics of TERT promoter mutation,
telomere length, and TERT expression in gastric cancers were studied. Materials and Methods: We sequenced
TERT promoter region in 104 gastric cancers. And telomere length and TERT expression was analyzed by using realtime
PCR. Results: TERT promoter mutation was found in 10.6% (11/104) of gastric cancers and associated with
advanced cancers (P = 0.02). The incidence of telomere shortening and TERT expression was 60.6% and 16.3%,
respectively. Diffuse type of gastric cancer tended to show higher expression of TERT (P = 0.07) and telomere-length
maintenance (P = 0.09). However, these telomere markers did not have prognostic value. Conclusion: These data
demonstrated that telomere status contribute to gastric carcinogenesis, however, it may be not a potential molecular
marker for predicting the prognosis.
Department
Dept. of Anatomy (해부학)
Publisher
School of Medicine
Citation
International Journal of Clinical and Experimental Pathology, Vol.9(2) : 1758-1763, 2016
Type
Article
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/33301
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
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