임신 중 혈전색전증

Other Titles
Thromboembolism in pregnancy
Authors
박준철
Department
Dept. of Obstetrics & Gynecology (산부인과학)
Issue Date
2016
Citation
Journal of the Korean Medical Association, Vol.59(1) : 8-13, 2016
ISSN
1975-8456
Abstract
Pregnancy-related venous thromboembolism (VTE) is one of the leading causes of maternal morbidity and mortality, developed in the antenatal and postpartum periods of pregnancy. The incidence of VTE during normal pregnancy is four- to six-fold higher than in the general reproductive aged female population. Physiologic changes such as hypercoagulable state, decreased venous capacitance, and reduced venous blood flow due to mechanical obstruction from gravid uterus compromise this condition. The prominent risk factors for VTE are thrombophilia, history of circulatory disease and previous VTE, preeclampsia and related disorders, and Cesarean section. In case of suspicion of VTE, prompt diagnosis and management are needed with the caution of potential adverse effects on the fetus. Low molecular weight heparin treatment is preferred due to better safety, more consistent bioavailability, ease of administration, lower risk of drug-related osteoporosis and thrombocytopenia and easier monitoring. For pregnant women with acute VTE, adjusted-dose subcutaneous low molecular weight heparin should be administrated antenatally and continued for at least 6 weeks postpartum. For prevention of VTE, mechanical prophylaxis such as physiotherapy, exercise, compression stockings, and intermittent pneumatic compression devices could be used. Thromboprophylaxis should also be considered for pregnant subjects with certain risks such as carriers of molecular thrombophilia or previously experienced VTE.
Keywords
Pregnancy(임신)Thromboembolism(혈전색전증)Low-molecular-weight heparin(저분자량헤파린)Thromboprophylaxis(혈전예방)
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/33353
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
Keimyung Author(s)
박준철
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