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Polymorphisms in the FAS and FASL genes and risk of lung cancer in a Korean population

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Affiliated Author(s)
한승범
Alternative Author(s)
Han, Sung Beom
Journal Title
Lung Cancer
ISSN
0169-5002
Issued Date
2006
Keyword
FASFASLPolymorphismLung cancersusceptibility
Abstract
Background

The FAS and FASL system play an important role in regulating extrinsic apoptotic pathway and inappropriate regulation of this signaling pathway contributes to lung tumorigenesis. Polymorphisms in the promoter region of the FAS (−1377G>A and −670A>G) and FASL (−844C>T) have been shown to alter the transcriptional activities of these genes. In order to evaluate the contribution of these polymorphisms to the risk of lung cancer, we carried out a case–control study in a Korean population.

Methods

The FAS and FASL genotypes were determined in 582 lung cancer patients and 582 healthy control subjects who were frequency-matched for age and gender.

Results

The FAS and FASL genotypes and the FAS haplotypes exhibited no apparent relationship with the risk of lung cancer. In addition, there was no significant interaction between the FAS and FASL polymorphisms in the development of lung cancer.

Conclusion

These results suggest that the FAS−1377G>A and −670A>G and FASL−844C>T polymorphisms do not significantly affect the susceptibility to lung cancer in Koreans.

Keywords
FAS;
FASL;
Polymorphism;
Lung cancer susceptibility
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
Sun Ha Park et al. (2006). Polymorphisms in the FAS and FASL genes and risk of lung cancer in a Korean population. Lung Cancer, 54(3), 303–308. doi: 10.1016/j.lungcan.2006.09.002
Type
Article
ISSN
0169-5002
DOI
10.1016/j.lungcan.2006.09.002
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33405
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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