Regulation of K+ channels may enhance wound healing in the skin
- Affiliated Author(s)
- 최태현; 한기환; 손대구; 김준형; 김상현
- Alternative Author(s)
- Choi, Tae Hyun; Han, Ki Hwan; Son, Dae Gu; Kim, Jun Hyung; Kim, Sang Hyon
- Journal Title
- Medical Hypotheses
- ISSN
- 0306-9877
- Issued Date
- 2008
- Abstract
- In the process of promoting wound healing, epidermal growth factor (EGF) activates protein kinase C,
protein tyrosine kinase and ERK MAPK (mitogen-activated protein kinase). The activation of these mediators in signal
pathways can regulate the operation of K+ channels. In addition, the K+ channel is involved with cell migration and
proliferation, both of which are requisite for wound healing. Recent studies, although not conducted on skin wounds,
have found that the K+ channel is associated with wound healing and that wound healing can be promoted by regulating
the K+ channels. Therefore, the authors hypothesize that healing of skin wounds could be promoted by regulating K+
channel distribution in skin keratinocytes or fibroblasts. We plan to conduct a study of the promotion of skin wound
healing using K+ channel regulators.
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