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Regulation of K+ channels may enhance wound healing in the skin

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Affiliated Author(s)
최태현한기환손대구김준형김상현
Alternative Author(s)
Choi, Tae HyunHan, Ki HwanSon, Dae GuKim, Jun HyungKim, Sang Hyon
Journal Title
Medical Hypotheses
ISSN
0306-9877
Issued Date
2008
Abstract
In the process of promoting wound healing, epidermal growth factor (EGF) activates protein kinase C,
protein tyrosine kinase and ERK MAPK (mitogen-activated protein kinase). The activation of these mediators in signal
pathways can regulate the operation of K+ channels. In addition, the K+ channel is involved with cell migration and
proliferation, both of which are requisite for wound healing. Recent studies, although not conducted on skin wounds,
have found that the K+ channel is associated with wound healing and that wound healing can be promoted by regulating
the K+ channels. Therefore, the authors hypothesize that healing of skin wounds could be promoted by regulating K+
channel distribution in skin keratinocytes or fibroblasts. We plan to conduct a study of the promotion of skin wound
healing using K+ channel regulators.
Department
Dept. of Plastic Surgery (성형외과학)
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
Dawon Kang et al. (2008). Regulation of K+ channels may enhance wound healing in the skin. Medical Hypotheses, 71(6), 927–929. doi: 10.1016/j.mehy.2008.05.038
Type
Article
ISSN
0306-9877
DOI
10.1016/j.mehy.2008.05.038
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33415
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Plastic Surgery (성형외과학)
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