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Multicenter surveillance of species distribution and antifungal susceptibilities of Candida bloodstream isolates in South Korea

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Affiliated Author(s)
류성열
Alternative Author(s)
Ryu, Seong Yeol
Journal Title
Medical Mycology
ISSN
1369-3786
Issued Date
2010
Keyword
Candidaantifungal susceptibilitycandidemiaazolesechinocandins
Abstract
Multicenter data on in vitro susceptibility of Candida bloodstream isolates to echinocandin antifungal agents is still lacking in South Korea. We performed a prospective multicenter study to determine the species distribution of Candida bloodstream isolates and their susceptibility to five antifungal agents, including caspofungin and micafungin. A total of 639 isolates were collected from 20 tertiary hospitals between September 2006 and August 2007. Antifungal susceptibilities were determined through the use of the CLSI broth microdilution method M27-A3. The overall species distribution was as follows; Candida albicans (38%), Candida parapsilosis (26%), Candia tropicalis (20%), Candida glabrata (11%), and miscellaneous Candida species (5%). Although C. parapsilosis and miscellaneous Candida species were less susceptible to both echinocandins, all 639 isolates were susceptible to both caspofungin and micafungin (MIC, ≤ 2 µg/ml). Nearly all isolates (99.7%) had a MIC ≤ 1 µg/ml to amphotericin B. Resistance to fluconazole and voriconazole was found in 0.8% and 0.3%, respectively, among all Candida isolates, with C. glabrata and C. krusei isolates displaying the greatest level of resistance. This is the largest multicenter candidemia study conducted in South Korea and shows that non-C. albicans Candida species, including C. parapsilosis, constitutes over 60% of all Candida species isolates recovered from the bloodstream. In addition, the rates of resistance to all five antifungals, including two echinocandins, are still low among bloodstream isolates in South Korea.

Keywords Candida, antifungal susceptibility, candidemia, azoles, echinocandins
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
SOOK-IN JUNG et al. (2010). Multicenter surveillance of species distribution and antifungal susceptibilities of Candida bloodstream isolates in South Korea. Medical Mycology, 48(4), 669–674. doi: 10.3109/13693780903410386
Type
Article
ISSN
1369-3786
DOI
10.3109/13693780903410386
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33416
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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