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Impact of IL-1 receptor antagonist gene polymorphism on schizophrenia and bipolar disorder

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Affiliated Author(s)
신동훈
Alternative Author(s)
Shin, Dong Hoon
Journal Title
Psychiatric Genetics
ISSN
0955-8829
Issued Date
2004
Keyword
cytokineinterleukin-1 receptor antagonistschizophreniabipolar disorderpolymorphism
Abstract
OBJECTIVES:

Variable levels of cytokines were observed in patients with schizophrenia and bipolar disorder, and an especially high level of interleukin-1 (IL-1) was detected in schizophrenia patients. It is known that IL-1 receptor antagonist (IL-1RA) binds to IL-1 receptors and inhibits the receptor binding of IL-1alpha and IL-1beta.

METHODS:

In this study, the association between the variable number of tandem repeats polymorphism of the IL-1RA gene and schizophrenia (n=269) and bipolar disorder (n=83) was investigated.

RESULTS:

The genotype distribution and allele frequency were significantly different between schizophrenic patients and the control group (P<0.05); however, there were no prominent differences between bipolar patients and the control group. The carriage rate for the IL1RN*2 allele was associated with higher risk of schizophrenia (odds ratio=2.24).

CONCLUSIONS:

This study indicates that IL-1RA could be a candidate gene for susceptibility to schizophrenia.

Psychiatric Genetics 2004, 14:165–167
Keywords: cytokine, interleukin-1 receptor antagonist, schizophrenia,
bipolar disorder, polymorphism
Department
Dept. of Preventive Medicine (예방의학)
Publisher
School of Medicine
Citation
S. J. Kim et al. (2004). Impact of IL-1 receptor antagonist gene polymorphism on schizophrenia and bipolar disorder. Psychiatric Genetics, 14(3), 165–167.
Type
Article
ISSN
0955-8829
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33457
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
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