Impact of IL-1 receptor antagonist gene polymorphism on schizophrenia and bipolar disorder
- Affiliated Author(s)
- 신동훈
- Alternative Author(s)
- Shin, Dong Hoon
- Journal Title
- Psychiatric Genetics
- ISSN
- 0955-8829
- Issued Date
- 2004
- Keyword
- cytokine; interleukin-1 receptor antagonist; schizophrenia; bipolar disorder; polymorphism
- Abstract
- OBJECTIVES:
Variable levels of cytokines were observed in patients with schizophrenia and bipolar disorder, and an especially high level of interleukin-1 (IL-1) was detected in schizophrenia patients. It is known that IL-1 receptor antagonist (IL-1RA) binds to IL-1 receptors and inhibits the receptor binding of IL-1alpha and IL-1beta.
METHODS:
In this study, the association between the variable number of tandem repeats polymorphism of the IL-1RA gene and schizophrenia (n=269) and bipolar disorder (n=83) was investigated.
RESULTS:
The genotype distribution and allele frequency were significantly different between schizophrenic patients and the control group (P<0.05); however, there were no prominent differences between bipolar patients and the control group. The carriage rate for the IL1RN*2 allele was associated with higher risk of schizophrenia (odds ratio=2.24).
CONCLUSIONS:
This study indicates that IL-1RA could be a candidate gene for susceptibility to schizophrenia.
Psychiatric Genetics 2004, 14:165–167
Keywords: cytokine, interleukin-1 receptor antagonist, schizophrenia,
bipolar disorder, polymorphism
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