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Clinical features of drug-induced parkinsonism based on [18F] FP-CIT positron emission tomography

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Affiliated Author(s)
유수연
Alternative Author(s)
You, Soo Yeoun
Journal Title
Neurological Sciences
ISSN
1590-1874
Issued Date
2015
Keyword
ParkinsonismDopamine receptor blocking agentsDopamine transporterPositron emission tomographyClinical characteristicsDifferential diagnosis
Abstract
Drug-induced parkinsonism (DIP) is the common
cause of parkinsonism. It is difficult to make a differentiation
between DIP and Parkinson’s disease (PD)
because there are no notable differences in the clinical
characteristics between the two entities. In this study, we
examined the relationship between the characteristics of
[18F] fluorinated-N-3-fluoropropyl-2-b-carboxymethoxy-3-
b-(4-iodophenyl)nortropane (FP-CIT) positron emission
tomography (PET) images and clinical features in DIP
patients. We retrospectively studied 76 patients with DIP
who underwent [18F] FP-CIT PET. We also enrolled 16
healthy controls who underwent it. We compared the
clinical characteristics between the DIP patients with normal
[18F] FP-CIT PET scans and those with abnormal ones.
Symmetric parkinsonism was more frequent in the patients
with normal [18F] FP-CIT PET scans as compared with
those with abnormal ones. Interval from drug intake to
onset of parkinsonism was longer in the patients with
abnormal [18F] FP-CIT PET scans as compared with those
with normal ones. A semi-quantitative analysis showed that
specific to non-specific binding ratios in the putamen was
lower in the patients with abnormal [18F] FP-CIT PET
scans as compared with those with normal ones and the
age-matched control group. Our results suggest that symmetric
parkinsonism was more prevalent, and the duration
of drug exposure before the onset of parkinsonism was
shorter in the patients with normal [18F] FP-CIT PET scans
as compared with those with abnormal ones.
Keywords Parkinsonism Dopamine receptor blocking
agents Dopamine transporter Positron emission
tomography Clinical characteristics Differential
diagnosis
Department
Dept. of Neurology (신경과학)
Publisher
School of Medicine
Citation
Hae-Won Shin et al. (2015). Clinical features of drug-induced parkinsonism based on [18F] FP-CIT positron emission tomography. Neurological Sciences, 36(2), 269–274. doi: 10.1007/s10072-014-1945-8
Type
Article
ISSN
1590-1874
DOI
10.1007/s10072-014-1945-8
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33508
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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