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Acute ophthalmoplegia (without ataxia) associated with anti-GQ1b antibody

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Affiliated Author(s)
이형
Alternative Author(s)
Lee, Hyung
Journal Title
Neurology
ISSN
0028-3878
Issued Date
2008
Abstract
Background: Anti-GQ1b antibody has been found in Miller Fisher syndrome (MFS), Guillain-Barre´
syndrome (GBS) with ophthalmoplegia, Bickerstaff brainstem encephalitis (BBE), and acute ophthalmoplegia
without ataxia (AO). The aim of this study was to determine the clinical features of
AO associated with anti-GQ1b antibody.
Methods: We retrospectively collected 34 patients with anti-GQ1b antibody syndrome. Of these
patients, 31 patients had ophthalmoplegia. The patients with ophthalmoplegia were classified
into MFS (n 13), AO (n 11), GBS with ophthalmoplegia (n 6), and BBE (n 1). We analyzed
clinical features and patterns of external and internal ophthalmoplegia of AO, and neuroophthalmologic
findings were compared with those of other anti-GQ1b syndromes with ophthalmoplegia.
Results: AO was observed in 11 (32.4%) of the 34 patients with anti-GQ1b antibody. External
ophthalmoparesis was present in all the patients and included mixed horizontal-vertical (n 7),
pure horizontal (n 3), and pure vertical gaze palsy (n 1). Binocular involvement was common,
but unilateral ophthalmoparesis was also observed in 27.3%. Other findings included ptosis (n
5, 45.5%) and internal ophthalmoplegia (n 6, 54.5%). Other anti-GQ1b antibody syndromes
had prominent neurologic signs including ataxia, weakness, and facial palsy in addition to ophthalmoplegia.
The patterns of neuro-ophthalmologic findings did not differ between AO and other
anti-GQ1b antibody syndromes with ophthalmoplegia.
Conclusions: Acute ophthalmoplegia (AO) commonly occurs in anti-GQ1b antibody syndrome and
manifests as various combinations of external and internal ophthalmoplegia. Internal ophthalmoplegia
is fairly common and unilateral involvement may occur in AO.
Department
Dept. of Neurology (신경과학)
Publisher
School of Medicine
Citation
S.-H. Lee et al. (2008). Acute ophthalmoplegia (without ataxia) associated with anti-GQ1b antibody. Neurology, 71(6), 426–429.
Type
Article
ISSN
0028-3878
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33510
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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