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The efficacy of methylprednisolone in aconite-induced myelo-optic neuropathy in the rabbit

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Affiliated Author(s)
권건영
Alternative Author(s)
Kwon, Kun Young
Journal Title
Neuro-ophthalmology
ISSN
0165-8107
Issued Date
2000
Keyword
Aconitemethylprednisolonemyelo-optic neuropathyVECP
Abstract
Studies in animals indicate that aconitine or aconite has
toxic effects on the visual system of a rabbit model. The toxic effects
include myelo-optic neuropathy, as proven in the visual evoked cortical
potentials (VECP) and histopathological studies. We investigated the
effect of intravenous high-dose methylprednisolone (MP) on myelooptic
neuropathy caused by aconite. The group treated with MP (30
mg/kg, twice a day, for 3 days followed by 15 mg/kg for 3 days) in
addition to aconite (1.5 ml/kg, equivalent to 0.7 mg/kg of aconitine)
was compared with an aconite only-injected group and a normal control
group. In the MP-treated group, increased recovery of onset latency,
peak latency, and amplitude in VECP was recorded at two weeks
(p<0.05) when comparied with the aconite only-injected group. In comparison
with the normal control group, the MP-treated group showed a
significant delay in onset latency at one and two months (p<0.05). The
MP-treated group also showed a significant difference in peak latency
at all observation periods when compared with the aconite only-injected
group. However, the amplitude in both the MP-treated group and the
aconite only-injected group increased at two months and did not show
a significant difference when compared with the normal control group.
Histopathological findings of the myelin sheath in the MP-treated group
generally showed less severe damage than in the aconite only-injected
group. The true benefits of high-dose MP were clear within two weeks.
The authors conclude that treatment with intravenous high-dose MP
immediately after aconite injection may have some beneficial effects
on the aconite-induced myelo-optic neuropathy, although such treatment
does not show a definite recovery.
Key words Aconite; methylprednisolone; myelo-optic neuropathy;
VECP
Department
Dept. of Pathology (병리학)
Publisher
School of Medicine
Citation
In Taek Kim et al. (2000). The efficacy of methylprednisolone in aconite-induced myelo-optic neuropathy in the rabbit. Neuro-ophthalmology, 24(1), 301–310.
Type
Article
ISSN
0165-8107
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33523
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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