Correlation of Primary Tumor FDG Uptake with Clinicopathologic Prognostic Factors in Invasive Ductal Carcinoma of the Breast

Authors
I. JoSeok Kil ZeonSung Hoon KimHae Won KimSun Hee KangSun Young KwonSu Jin Kim
Department
Dept. of Nuclear Medicine (핵의학); Dept. of Surgery (외과학); Dept. of Pathology (병리학)
Issue Date
2015
Citation
Nuclear Medicine and Molecular Imaging, Vol.49(1) : 19-25, 2015
ISSN
1869-3474
Abstract
Purpose The purpose of this study was to investigate the correlation of primary tumor FDG uptake to clinicopathological prognostic factors in invasive ductal carcinoma of the breast. Methods We retrospectively reviewed 136 of 215 female patients with pathologically proven invasive ductal breast cancer from January 2008 to December 2011 who underwent F-18 FDG PET/CT for initial staging and follow-up after curative treatment with analysis of estrogen receptor (ER), progesterone receptor (PR) and human epithelial growth factor receptor 2 (HER2). The maximum standardized uptake value (SUVmax) of the primary breast tumor was measured and compared with hormonal receptor and HER2 overexpression status. Results The high SUVmax of primary breast tumors is significantly correlated with the clinicopathological factors: tumor size, histologic grade, TNM stage, negativity of ER, negativity of PR, HER2 overexpression and triple negativity. The recurrent group with non-triple negative cancer had a higher SUVmax compared with the non-recurrent group, though no significant difference in FDG uptake was noted between the recurrence and non-recurrent groups in subjects with triple-negative cancer. Lymph node involvement was the independent risk factor for cancer recurrence in the multivariate analysis. Conclusions In conclusion, high FDG uptake in primary breast tumors is significantly correlated with clinicopathological factors, such as tumor size, histologic grade, TNM stage, negativity of the hormonal receptor, HER2 overexpression and triple negativity. Therefore, FDG PET/CT is a helpful prognostic tool to direct the further management of patients with breast cancer. Keywords F-18 FDG . PET/CT . Breast cancer . Triple negative . Invasive ductal carcinoma
Keywords
F-18 FDGPET/CTBreast cancerTriple negativeInvasive ductal carcinoma
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/33564
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
Keimyung Author(s)
김해원; 강선희; 권선영
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