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Correlation of Primary Tumor FDG Uptake with Clinicopathologic Prognostic Factors in Invasive Ductal Carcinoma of the Breast

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Affiliated Author(s)
김해원강선희권선영
Alternative Author(s)
Kim, Hae WonKang, Sun HeeKwon, Sun Young
Journal Title
Nuclear Medicine and Molecular Imaging
ISSN
1869-3474
Issued Date
2015
Keyword
F-18 FDGPET/CTBreast cancerTriple negativeInvasive ductal carcinoma
Abstract
Purpose The purpose of this study was to investigate the
correlation of primary tumor FDG uptake to clinicopathological
prognostic factors in invasive ductal carcinoma of the
breast.
Methods We retrospectively reviewed 136 of 215 female
patients with pathologically proven invasive ductal breast
cancer from January 2008 to December 2011 who underwent
F-18 FDG PET/CT for initial staging and follow-up after
curative treatment with analysis of estrogen receptor (ER),
progesterone receptor (PR) and human epithelial growth factor
receptor 2 (HER2). The maximum standardized uptake
value (SUVmax) of the primary breast tumor was measured
and compared with hormonal receptor and HER2 overexpression
status.
Results The high SUVmax of primary breast tumors is significantly
correlated with the clinicopathological factors: tumor
size, histologic grade, TNM stage, negativity of ER,
negativity of PR, HER2 overexpression and triple negativity.
The recurrent group with non-triple negative cancer had a
higher SUVmax compared with the non-recurrent group,
though no significant difference in FDG uptake was noted
between the recurrence and non-recurrent groups in subjects
with triple-negative cancer. Lymph node involvement was the
independent risk factor for cancer recurrence in the multivariate
analysis.
Conclusions In conclusion, high FDG uptake in primary
breast tumors is significantly correlated with clinicopathological
factors, such as tumor size, histologic grade, TNM stage,
negativity of the hormonal receptor, HER2 overexpression
and triple negativity. Therefore, FDG PET/CT is a helpful
prognostic tool to direct the further management of patients
with breast cancer.
Keywords F-18 FDG . PET/CT . Breast cancer .
Triple negative . Invasive ductal carcinoma
Department
Dept. of Nuclear Medicine (핵의학)
Dept. of Surgery (외과학)
Dept. of Pathology (병리학)
Publisher
School of Medicine
Citation
I. Jo et al. (2015). Correlation of Primary Tumor FDG Uptake with Clinicopathologic Prognostic Factors in Invasive Ductal Carcinoma of the Breast. Nuclear Medicine and Molecular Imaging, 49(1), 19–25. doi: 10.1007/s13139-014-0296-y
Type
Article
ISSN
1869-3474
DOI
10.1007/s13139-014-0296-y
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33564
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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