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Antidepressant Prescribing Patterns in Korea: Results from the Clinical Research Center for Depression Study

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Affiliated Author(s)
정성원
Alternative Author(s)
Jung, Sung Won
Journal Title
Psychiatry investigation
ISSN
1738-3684
Issued Date
2011
Keyword
Antidepressive agentsDepressionPrescriptionsKoreaCRESCEND
Abstract
Objective

This study aimed to investigate antidepressant prescribing patterns, including initial choice, switching and combining, and concomitant use of non-antidepressant agents, for depressive disorders in naturalistic clinical care settings in Korea.


Methods

Patients with depressive disorder were recruited from both outpatient and inpatient settings in 18 hospitals from all over Korea. Treatment was performed in naturalistic patterns based on each clinician's decision. Data were collected on the prescription of antidepressants and concomitant agents from baseline to 12-week follow-up.


Results

Selective serotonin reuptake inhibitors (SSRIs) were the most commonly prescribed initial antidepressant (48.9%), followed by newer dual-action antidepressants (45.8%). When an SSRI was the initial antidepressant, 46.2% of patients whose medication was changed were moved to newer dual-action antidepressants, and 67.4% of combination cases were combined with newer dual-action ones. When a newer dual-action antidepressant was the initial antidepressant, 70.6% of patients whose medication was changed were moved to SSRIs, and other antidepressants including tricyclic antidepressants were most commonly added for combination treatment (50% of combination cases). During the treatment period, 20.6% of antidepressants prescribed were augmented by non-antidepressant agents, and 75.1% were used concomitantly with anxiolytics or hypnotics. The most commonly used concomitant non-antidepressant agent was quetiapine.


Conclusion

The selection of antidepressants and the concomitant use of non-antidepressant agents are becoming increasingly diversified, and the results of this study reflect changes in the prescribing pattern in actual Korean practices.

Keywords: Antidepressive agents, Depression, Prescriptions, Korea, CRESCEND
Department
Dept. of Psychiatry (정신건강의학)
Publisher
School of Medicine
Citation
Kyung-Yeol Bae et al. (2011). Antidepressant Prescribing Patterns in Korea: Results from the Clinical Research Center for Depression Study. Psychiatry investigation, 8(3), 234–244. doi: 10.4306/pi.2011.8.3.234
Type
Article
ISSN
1738-3684
DOI
10.4306/pi.2011.8.3.234
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33627
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Psychiatry (정신건강의학)
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